祁峰 教授

一，个人简介

祁峰，博士，福建师范大学生命科学学院教授，博士生导师。入选福建省“高校杰出青年科研人才培育计划”。

2003年本科毕业于河南大学生命科学学院；2011年博士毕业于北京理工大学生命学院

工作经历： 2014年至今  福建师范大学生命科学学院 副教授、教授

                  2017-2018年 美国莱斯大学（Rice University）访问学者

                  2012-2014年  清华大学化工系 博士后

      2011-2012年  天津科技大学生物工程学院 讲师

在相关领域发表学术论文50余篇，其中SCI收录30余篇，授权专利12项，参编著作2部。

联系方式：Email: f.qi@fjnu.edu.cn  

研究方向：微生物代谢工程、生物能源、食品微生物与发酵技术

招收博士研究生方向：微生物学（微生物分子生物学与合成生物学）

招收硕士研究生方向1. 微生物学 2. 生物化学与分子生物学 3. 生物技术与工程（专业学位）

二、主要承担项目

2023-2026年 圆红冬孢酵母碳通量调控生物量和油脂同步积累的特殊机制研究，国家自然科学基金面上项目（32272287），主持；

2023-2027年 基于宿主的抗感染新药靶标的发现及新兽药筛选，国家重点研发计划子课题（2022YFD1802104），参与；

2014-2017年 纤维素可及度新型表征方法的建立及其用于纤维素预处理关键因素的研究，国家自然科学基金青年项目（21406130），主持；

2020-2023年 圆红冬孢酵母突变菌株合成番茄红素的特殊分子机制研究，福建省自然基金面上项目（2021J01168），主持；

2020-2024年 工程化类球红细菌生产辅酶Q₁₀技术及其应用开发，横向项目，主持；

2013-2014年 透明质酸合成酶决定透明质酸分子量关键因素的研究，中国博士后基金（2013M530636），主持；

2015-2017年 福建省高校杰出青年科研人才培育计划项目，主持；

2012-2015年 海西绿色生物制造技术协同创新中心培育项目，福建省教育厅（闽教科[2013751]号）参与

三，教学工作

承担本科生《工程制图与AutoCAD》、《生化工程》、《生物工程设备》、《生物分离工程实验》

承担研究生《生物工程研究进展》等课程的教学工作

四，获奖情况

2018年获  国际基因工程机器大赛（iGEM）（FJNU-China团队指导教师）金奖

2017年获  福建师范大学第二届“五一劳动奖章”

2016年获  福建省“青年教师教学技能大赛”一等奖

2016年获  福建师范大学“青年教师教学技能大赛”一等奖

2017年获  福建师范大学“集英教学奖”

五，论文及著作

 [1] Dou Jin, Xinru Bao, Jinhua Yang, Chenxi Li, Wenjin He, Jianzhong Huang*, Bingmei Wang,

 Weibin Wu, Feng Qi*. Integrated and enhanced coassimilation of formate and acetate for efficient utilization of lignocellulosic hydrolysate. ACS Sustainable Chemistry & Engineering. 2024, 12, 2802-2812.

 [2] Yu Su, Qingchen Li,Suyi Gu, Qinghao Liu, Wenjin He*, Jianzhong Huang, Weibin Wu,  Feng Qi*. Development of biochar-based whole-cell biocatalysts for the production of l-tryptophan and l-phenylalanine.ACS Sustainable Chemistry & Engineering. 2023, 25, 9412–9423.

 [3]Peijie Shen, Suyi Gu, Dou Jin, Yu Su, Hongxuan Wu, Qingchen Li, Jinhua Yang, Wenjin He, Jianzhong Huang, Feng Qi*. Engineering metabolic pathways for cofactor self-sufficiency and serotonin production in Escherichia coli.ACS Synthetic Biology. 2022, 11, 8, 2889–2900.

 [4]Yixian Luo, Dou Jin, Wenjin He, Jianzhong Huang, Aicheng Chen, Feng Qi^*.A SiO₂ Microcarrier with an opal-like structure for cross-linked enzyme immobilization.Langmuir. 2021, 37:14147-14156.

 [5] Hongxuan Wu, Jinhua Yang, Peijie Shen, Qingchen Li, Weibin Wu, Xianzhang Jiang, Lina Qin, Jianzhong Huang^*, Xiao Cao, Feng Qi^*. High-level production of indole-3-acetic acid in the metabolically engineered Escherichia coli. Journal of Agricultural & Food Chemistry. 2021, 69:1916-1924.

 [6] Xuehai Zheng, Rongfei Hu, Duo Chen, Jiannan Chen, Wenjin He, Luqiang Huang, Chentao Lin, Huibin Chen, Youqiang Chen, Jinmao Zhu, Feng Qi, Ting Xue^*.Lipid and carotenoid production by the Rhodosporidium toruloides mutant in cane molasses. Bioresource Technology. 2021, 326: 124816.

 [7] Feng Qi^*, Peijie Shen, Rongfei Hu, Ting Xue, Xianzhang Jiang, Lina Qin, Youqiang Chen, Jianzhong Huang. Carotenoids and lipid production from Rhodosporidium toruloides cultured in tea waste hydrolysate. Biotechnology for Biofuels. 2020, 13:74.

 [8] Yanna Zhao, Boyan Lv, Fengqi Sun, Jiafeng Liu, Yan Wang, Yuanyuan Gao, Feng Qi, Zengyi Chang, Xinmiao Fu. Rapid freezing enables aminoglycosides to eradicate bacterial persisters via enhancing mechanosensitive channel MscL-mediated antibiotic uptake. mBio. 2020, 11. pii: e03239-19.

 [9] Man Xu,  Hongxuan Wu, Peijie Shen, Xianzhang Jiang, Xueduan Chen, Jinxin Lin, Jianzhong Huang^*, Feng Qi^*. Enhancement of NADPH availability for coproduction of coenzyme Q10 and farnesol from Rhodobacter sphaeroides. Journal of Industrial Microbiology & Biotechnology. 2020, 47: 263-274. 

 [10] Xueduan Chen, Xianzhang Jiang, Man Xu, Mingliang Zhang, Runye Huang, Jianzhong Huang^*, Feng Qi^*. Co-production of farnesol and coenzyme Q10 from metabolically engineered Rhodobacter sphaeroides. Microbial Cell Factories. 2019, 18: 98.

[11] TianLi, Nan Liu, Xianjin Ou, Xuebing Zhao^*, Feng Qi^*, Jianhzong Huang, Dehua Liu. Visualizing cellulase adsorption and quantitatively determining cellulose accessibility with an updated fungal cellulose-binding module-based fluorescent probe protein. Biotechnology for Biofuels. 2018, 11:105

[12] WeiBin Wu, XiaoLei Guo, MingLiang Zhang, QingGeng Huang, Feng Qi^*, Jianhzong Huang^*.Enhancement of L-phenylalanine production in Escherichia coli by heterologous expression of Vitreoscilla hemoglobin. Biotechnology & Applied Biochemistry. 2018 65: 476-483.

[13] Feng Qi, Chandresh Thakker, Fayin Zhu, Matthew Pena, Ka-Yiu San, George N. Bennett^*. Improvement of butanol production in Clostridium acetobutylicum through enhancement of NAD(P)H availability.Journal of Industrial Microbiology & Biotechnology. 2018, 45: 993-1002.

[14] Feng Qi, Mingliang Zhang, Youwei Chen, Xianzhang Jiang, Jinxin Lin, Xiao Cao, Jianzhong Huang^*. A lignocellulosic hydrolysate-tolerant Aurantiochytrium sp. mutant strain for docosahexaenoic acid production. Bioresource Technology.2017, 227: 221–226.

[15] Feng Qi^*, Limei Zou, Xianzhang Jiang, Shaoli Cai, Mingliang Zhang, Xuebing Zhao, Jianzhong Huang^*. Integration of heterologous 4-hydroxybenzoic acid transport proteins in Rhodobacter sphaeroides for enhancement of coenzyme Q₁₀ production. RSC Advances. 2017.7: 17346-17352.

[16] Feng Qi, Xuebing Zhao, Y Kitahara, Tian Li, Xianjin Ou, Wei Du^*, Dehua Liu. Integrative transcriptomic and proteomic analysis of the mutant lignocellulosic hydrolyzate-tolerant Rhodosporidium toruloides.Engineering in Life Sciences. 2017, 17:249-261.

 [17]Feng Qi, Yuki Kitahara, Zitian Wang, Xuebing Zhao, Wei Du^*, Dehua Li. Novel mutant strains of Rhodosporidium toruloides by plasma mutagenesis approach and their tolerance for inhibitors in lignocellulosic hydrolyzate. Journal of Chemical Technology & Biotechnology. 2014, 89: 735–742.

 [18] Feng Qi, Yanli Liu, Imdad Kaleem, Chun Li^*. Transcriptional profiling of protein expression related genes of pichia pastoris under simulated microgravity. Plos One.2011; 6:e26613.

[19]Feng Qi, Imdad Kaleem, Bo Lv, Xiaoxiao Guo, Chun Li^*. Enhancement of recombinant β-D-glucuronidase production under low-shear modeled microgravity in Pichia pastoris. Journal of Chemical Technology & Biotechnology.2011, 86: 505–511.

 [20] Feng Qi, DaZhang Dai, Yanli Liu, Imdad Kaleem, Chun Li^*. Effects of Low- Shear Modeled Microgravity on the Characterization of Recombinant β-D-Glucuronidase Expressed in Pichia pastoris, Applied Biochemistry & Biotechnology, 2011, 163: 162-172.   

[21] Feng Qi, Lei Sun, MingLiang Zhang, XianZhang Jiang, Xiao Cao, Jianzhong Huang^*. Alpha-Linolenic Acid Production by the Mutant Rhodosporidium toruloides. International Journal of Food Engineering. 2016, 2:140-146.

[22] Xuebing Zhao, Feng Qi (Co-first Author), ChongliYuan, WeiDu, DehuaLiu Lipase-catalyzed process for biodiesel production: Enzyme immobilization, process simulation and optimization.Renewable & Sustainable Energy Reviews. 2015, 44:182–197.（“SCI高被引论文”）

[23] Genlin Zhang, Feng Qi (Co-first Author), Haiyang Jia, Changling Zou and Chun Li^*. Advances in bioprocessing for efficient biomanufacture.RSC Advances. 2015, 5, 52444.

[24] Hyun Hwang, Feng Qi (Co-first Author), Chong Yuan, Xuebing Zhao^*, Doraiswami Ramkrishna, Dehua Liu, Arvind Varma. Lipase-Catalyzed process for biodiesel production:protein engineering and lipase production. Biotechnology and Bioengineering. 2014, 111: 639–653.

[25] Jie Huangfu, Feng Qi (Co-first Author), Hongwei Liu, Hanfa Zou, Muhammad Ahmed, Chun Li^*. Novel helper factors influencing recombinant protein production in Pichia pastoris based on proteomic analysis under simulated microgravity. Applied Microbiology & Biotechnology, 2015, 99: 653-665.

[26] Liang Xiang, Feng Qi (Co-first Author), DaZhang Dai, Chun Li^*. Simulated microgravity affects growth of Escherichia coli and recombinant β-D-glucuronidase production. Applied Biochemistry & Biotechnology,2010, 162: 654-661.

[27] Tian Li, Qi Fang, Hongmei Chen, Feng Qi, Xianjin Ou, Xuebing Zhao^*, Dehua Liu.

 Solvent-based delignification and decrystallization of wheat straw for efficient enzymatic hydrolysis of cellulose and ethanol production with low cellulase loadings. RSC Advances, 2017, 7: 10609-10617

[28] XianzhangJiang, Hongjiao Liu, Yongchao Niu, Feng Qi, Mingliang Zhang, Jianzhong Huang^*. Functional identification and regulatory analysis of Δ6-fatty acid desaturase from the oleaginous fungus Mucor sp. EIM-10. Biotechnology Letters. 2017, 39:453-461.

[29] Yan Zhou, Hongmei Chen, Feng Qi, Xuebing Zhao^*, Dehua Liu. Non-ionic surfactants do not consistently improve the enzymatic hydrolysis of pure cellulose. Bioresource Technology. 2015, 182: 136–143.

[30] Xuebing Zhao^*, Yuichi Morikawa, Feng Qi, Jing Zeng, Dehua Liu. A novel kinetic model for polysaccharide dissolution during atmospheric acetic acid pretreatment of sugarcane bagasse. Bioresource Technology. 2014, 151: 128–136.

[31] Mingliang Zhang, Weibin Wu, Xiaolei Guo, You Weichen, Feng Qi, Xianzhang Jiang, Jianzhong Huang^*.Mathematical modeling of fed-batch fermentation of Schizochytrium sp. FJU-512 growth and DHA production using a shift control strategy. 3 Biotech. 2017, 8: 162.

[32] Ting Tang, Feng Qi, Hongjuan, Liu, Dehua Liu^*. Recent developments in microbial production of 1 3-propanediol. Biofuels. 2013, 4(6): 651–667.

[33] Yanli Liu, Jie Huangfu, Feng Qi, Imdad Kaleem, Wenwen E, Chun Li^*. Effects of a non-conservative sequence on the properties of β-glucuronidase from Aspergillus terreus Li-20. Plos One. 2012, 7(2):e30998.

[34] Yan Gao, Zhan Sun, Feng Qi, Lixiang Chen, Huiping Lou, Xianyuan Wang, Yuanming Qi^*. Identification of a new broad-spectrum CD8+ T cell epitope fromover-expressed antigen COX-2 in esophageal carcinoma. Cancer Letters, 2009, 284: 55–61.

[35] Chao Wang, Xiao-Xiao Guo, Xiao-Yan Wang, Feng Qi, Shi-Jiang Feng, Chun Li^*, Xiao-Hong Zhou. Isolation and characterization of three fungi with the potential of transforming glycyrrhizin. World J Microbiol Biotechnol, 2013; 29: 781-788. 

参编著作：

[1] 《细胞培养工程》高等教育出版社, 北京，2012.（国家普通高等教育“十一五”规划教材）

[2] 《Nanotechnology for Bioenergy and Biofuel Production》， Chapter 6：Hierarchy Nano- and Ultrastructure of Lignocellulose and Its Impact on the Bioconversion of Cellulose》，出版社：Springer International Publishing, Germany, 2017，排名第二