一、个人简介
沈阳坤博士，副教授，硕士生导师
福建省高层次人才C类，福建省优秀创新创业导师
福建省抗癌协会肿瘤合成生物医药专委会常务委员兼秘书
福建省免疫学会青年委员会常务委员
福建省免疫学会肿瘤免疫与生物治疗专业委员会委员
二、研究方向和领域
聚焦于cGAS-STING通路的免疫调控机制及其在癌症和自身免疫病中的病理作用，同时基于此开展细胞基因治疗的策略开发与临床转化工作。具体如下：
1、肿瘤的发生与耐药机制。
2、肿瘤的基因与免疫治疗研究。
3、CRISPR/Cas9基因修饰技术的开发应用。
4、细胞治疗（干细胞、Tils细胞、NK细胞、DC细胞等）在疾病中的应用与机制研究。
三、研究成果
先后主持/参与国家自然科学基金青年科学基金项目（C类）1项，国家自然科学基金重点项目2项，国家自然科学基金应急管理项目1项，福建省级重点项目5项、福建省自然科学基金3项。相关工作在Trends Pharmacol Sci.、Anal. Chem.、J Transl Med、Virulence、Cell Mol Life Sci等期刊发表SCI文章/专著30余篇，多次受邀编写Springer Nature 出版集团旗下的Methods in Molecular Biology系列丛书。授权国家发明专利2项，正在审查3项。
四、教学成果
指导学生参加中国国际大学生创新大赛、全国大学生互联网＋创新创业大赛、全国大学生生命科学竞赛等比赛，多次获得国家级奖项（国家级金奖1项、银奖1项、铜奖1项和三等奖1项）和省级奖项（福建省金奖2项、银奖2项和二等奖1项）。主讲本科生基础必修课《生物化学》。
五、招生方向
0710生物学——071000生物学
0836生物工程——083600生物工程
0860生物与医药硕士——086001生物技术与工程
六、部分代表性论著
1.Xiangqian Zhao, Hucheng Zhang, Shuzhen Xu, Lingling Mei, Zhihua Feng, Dawei Wang, Weiwei Huang, Yangkun Shen. Syncytium-Forming HSV-1 in Cancer Gene Therapy: From Molecular Mechanisms to Clinical Translation. Virulence, 2026,17,1.
2.Gao, Yong; Fu, Shaofei; Gu, Biaofeng; He, Chu; Ke, Peiru; Xie, Xingyu; Shen, Yangkun; Chen, Qi. Trace Cu²⁺-Catalyzed Oxidative Fluorogenic Assay for Dopamine Imaging in Living Cells. Analytical Chemistry, 2026, 98(25):18559-18567.
3.Yi Ye, Jinyun Wu, Tao Sun, Minghong Huang, Jiaping Pan, Danjing Hu, Keying Chen, Dawei Wang, Chenxi Wang, Yangkun Shen, Qi Chen, Baolin Huang. Immunomodulating red blood cell coating for mitigation of foreign body reactions. Engineered Regeneration. 2025, 6, 218-229.
4.Lin, Y.; Luo, S.; Wei, J.; Lin, S.; Wang, D.; Zhao, X.; Feng, Z.; Shen, Y*.; Chen, Q. Limitations of CAR-T-Cell Therapy in Hematologic Malignancies: Focusing on Antigen Escape and T-Cell Dysfunction. Int. J. Mol. Sci. 2025, 26, 9669.
5.Yangkun Shen, Hucheng Zhang, Mengzhou Xue†, Chunfu Zheng†, and Qi Chen†.HSV-1 as a Gene Delivery Platform for Cancer Gene Therapy.Trends in pharmacological sciences, 2025, 3.
6.Zhihua Feng†, Xinyan He†, Minhua Lin†, Heng Zhao†, Yao Chen, Jianghua Chen, Zhaolong Li, Yangkun Shen*, Jianxin Chen*, Qi Chen*. Genome-wide CRISPR/Cas9 screening identified ALG5, ALG6, NF2 and FUT8 as key host factors for Transmissible Gastroenteritis Virus infection. Int J Biol Macromol, 2025, 333(Pt 2):148770.
7.Feng Z, Fu Y, Yang S, Zhao H, Lin M, Liu C, Huang W, He X, Chen Y, Chen J, Shen Y†, Li Z†,Chen Q†. Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection. Cell Mol Life Sci. 2025, 82(1):136.
8. Zhijian Huang, Xiangqian Zhao, Zirong Jiang, Xiaoting Qiu, Xinhao Sun, Dawei Wang, Hucheng Zhang, Qi Chen, Ruirong Tan, and Yangkun Shen†. IP6K2 mutations as a novel mechanism of resistance to oncolytic virus therapy. JTransl Med, 2025, 23, 311.
9.Chenxi Wang, Xiangqian Zhao, Dawei Wang, Jinyun Wu, Jizhen Lin, Weiwei Huang, Yangkun Shen† and Qi Chen†. Analysis of prognostic factors and nomogram construction for postoperative survival of triple-negative breast cancer. Frontiers in Immunology, 2025 Apr 7;16:1561563.
10.Feng Z, Zhao H, Li Z, Lin M, Huang W, Liu C, Shen Y†, Chen Q†. The Infectivity and Pathogenicity Characteristics of a Recombinant Porcine Epidemic Diarrhea Virus, CHFJFQ. Viruses. 2025, 17(3):401.
11.Yangkun Shen, Xiangqian Zhao, Lizhu Chen, Xin Wang, Dawei Wang, Hucheng Zhang, Zuda Zheng, Weiwei Huang, Chunfu Zheng, Yu Chen, Chuanben Chen, Qi Chen. A modified HSV-1 oncolytic virus reconciles antiviral and antitumor immunity via promoting IFNβ expression and inhibiting PKR. Int J Biol Macromol, 2024, 274（2），133297.
12. Guohao Li, Xiangqian Zhao, Zuda Zheng, Hucheng Zhang, Yundi Wu, Yangkun Shen* and Qi Chen*.cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors. Cell Mol Life Sci, 2024, 81:149.
13.Huang W, Wang C, Shen Y, Chen Q, Huang Z, Liu J, Lin X, Wang L, Wu F, Chen X, Li N, Hong Y, Chen M, Li J, Huang C. A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer. BMC Cancer. 2024, 24(1):39.
14.Dawei Wang, Heng Zhao, Yangkun Shen* and Qi Chen*. A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions [J]. Frontiers in Immunology, 2022,344.
15. Changhua Zhuo*, Qiang Ruan, Xiangqian Zhao, Yangkun Shen* and Ruirong Lin.CXCL1 Promotes Colon Cancer Progression Through Activation of NF-κB/P300 Signaling Pathway.Biology Direct, 2022, 17:34.
16.Chiang ZC, Fang S, Shen YK, Cui D, Weng H, Wang D, Zhao Y, Lin J, Chen Q. Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo. Front Oncol. 2022; 12:857927.
专著：
1、Shen Y, Zhao X, Zheng C, Chen Q. CRISPR-Mediated Construction of Gene-Knockout Mice for Investigating Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:61-74.
2、Shen Y, Feng Z, Zheng C, Chen Q. CRISPR-Mediated Library Screening of Gene-Knockout Cell Lines for Investigating Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:51-60.
3、Feng Z, Shen Y, Zheng C, Chen Q. CRISPR-Mediated Viral Gene Knockout to Investigate Viral Evasion of Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:41-50.
七、联系方式
E-mail：shenyk@fjnu.edu.cn