吴军军
一、个人简介
博士，副教授，博士生导师，生命科学学院院务委员。福建省优青，福建省引进高层次人才C类，病原微生物感染机理与干预福建省高校重点实验室学术带头人。湖北随州人，2021年博士毕业于清华大学化学系。主要从事病原微生物的疫苗和免疫治疗研究。主持国家自然科学基金青年基金、国家自然科学基金重点项目子课题（经费112万）、福建省自然科学基金优青项目、福建省自然科学基金面上项目、福建省中青年教师教育科研项目，在CCS Chem.、Adv. Funct. Mater.、Adv. Sci.、Acta Pharm. Sin. B.等国际期刊发表SCI论文10余篇，授权发明专利5项。兼任福建师范大学学报（自然科学版）青年编委，Health and Metabolism期刊青年编委。
二、研究方向和领域
病原微生物的疫苗和免疫治疗研究。
三、主要科研项目
1.国家自然科学基金委重点项目子课题，112万，2023-2028，主持；
2.国家自然科学基金委青年基金，30万，2024-2027，主持；
3.福建省自然科学基金优青项目，20万，2025-2028，主持；
4.福建省自然科学基金面上项目，10万，2023-2026，主持；
5.福建省中青年教师教育科研项目，1万，2023-2024，主持；
6.福建师范大学生命科学学院科技创新团队培育计划，100万，2023-2026，参与；
7.国家自然科学基金委面上项目，65万元，2017-2020，参与；
8.国家自然科学基金委中以合作项目，170万元，2016-2019，参与；
9.清华大学新冠疫情科研专项春风基金，60万元，2020-2022，参与。
四、主要获奖成果
1. 福建省优青
2. 福建省引进高层次人才C类
五、代表性论著
1.Junjun Wu, Zhennan Zhao, Hongsheng Wu, Sihuang Lin, Lin Huang, Guanjie Chen, Yi Yang, Hong Wang, Huijie Yan, Yonghui Shi, Liuyu Zhu, Guosheng Hu, Liling Zheng*, Songying Ouyang*.Novel Swelling-Lytic Cell Death Triggered by Cargo-Free Ionizable Lipid Nanoparticles. Advanced Science, 2025, e09208. (一区TOP，IF=14.1)
2.Jun-Jun Wu*, Hong Wang, Pu Gao, Songying Ouyang*. Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases. Acta Pharmaceutica Sinica B, 2024, 14, 4195-4227.(一区TOP，IF=14.7)
3.Jun-Jun Wu#, Guan-Jie Chen#, Chen-Yuan Fan#, Fan Shen#, Yi Yang, Wei Pang, Zhen-Nan Zhao, Hong-Xin Guan, Huan Wu, Ying Lu, Ya-Juan Fu, Qi Chen, Yong-Tang Zheng* and Songying Ouyang* An Adjustable Adjuvant STINGsome for Tailoring the Potent and Broad Immunity against SARS-CoV-2 and Monkeypox Virus via STING and Necroptosis. Advanced Functional Materials, 2023, 2306010. (一区TOP，IF=19，BioArtMed、X-MOL、奇物论报道)
4.Jun-Jun Wu#, Fang-Yuan Chen#, Bei-Bei Han#, Hong-Qing Zhang#, Lang Zhao, Zhe-Rui Zhang, Juan-Juan Li, Bo-Dou Zhang, Ya-Nan Zhang, Yu-Xin Yue, Hong-Guo Hu, Wen-Hao Li, Bo Zhang*, Yong-Xiang Chen*, Dong-Sheng Guo* and Yan-Mei Li*.CASTING: A Potent Supramolecular Strategy to Cytosolically Deliver STING Agonist for Cancer Immunotherapy and SARS-CoV-2 Vaccination. CCS Chemistry, 2023, 5, 885. (Front Cover, IF=11.2, 中国化学会旗舰期刊， X-MOL, 奇物论, 化学加等报道)
5.Jun-Jun Wu, Lang Zhao, Bei-Bei Han, Hong-Guo Hu, Bo-Dou Zhang, Wen-Hao Li, Yong-Xiang Chen, Yan-Mei Li*. A novel STING agonist for cancer immunotherapy and a SARS-CoV-2 vaccine adjuvant. Chem Commun, 2021, 57:504-507. (二区TOP，IF=6.22，ACS Central Science杂志高亮点评)
6.Jun-Jun Wu, Lang Zhao, Hong-Guo Hu, Wen-Hao Li, Yan-Mei Li*. Agonists and inhibitors of the STING pathway: Potential agents for immunotherapy. Med Res Rev, 2020, 40:1117-1141. (一区TOP，IF=9.3)
7.Jun-Jun Wu, Wen-Hao Li, Pu-Guang Chen, Bo-Dou Zhang, Hong-Guo Hu, Qian-Qian Li, Lang Zhao, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li*. Targeting STING with cyclic di-GMP greatly augmented immune responses of glycopeptide cancer vaccines. Chem Commun, 2018, 54:9655-9658. (一区TOP，IF=6.29)
8.Shao-Hua Zhuo#, Jun-Jun Wu#, Lang Zhao, Wen-Hao Li, Yu-Fen Zhao, Yan-Mei Li*. A Chitosan-Mediated Inhalable Nanovaccine against SARS-CoV-2. Nano Res, 2022, 15, 4191. (#共同一作，一区TOP，IF=10.27，引用次数4)
9.Yong-Fang Zheng*, Jun-Jun Wu*. Overcoming STING Agonists Barriers: Peptide, Protein, Biomembrane-based Biocompatible Delivery Strategies. Chem Asian J, 2022, 17(6): e202101400. (Front Cover)
10.Zhijie Lian, Lingying Zheng, Shuya Liu, Junjie Zhang, Jie Zhou, Junjun Wu, Songying Ouyang, Jingying Li*, Huanghao Yang*.Breaking Endosomal Barriers: Thiol-Mediated Uptake Lipid Nanoparticles for Efficient mRNA Vaccine Delivery. Journal of the American Chemical Society, 2025, 147(35):31530-31540.
11.Wen-Hao Li, Jun-Jun Wu, Lie Wu, Bo-Dou Zhang, Hong-Guo Hu, Lang Zhao, Zhi-Bin Li, Xue-Feng Yu*, Yan-Mei Li*. Black phosphorous nanosheet: A novel immune-potentiating nanoadjuvant for near-infrared-improved immunotherapy. Biomaterials, 2021, 273:120788.
12.Bo-Dou Zhang, Jun-Jun Wu, Wen-Hao Li, Hong-Guo Hu, Lang Zhao, Pei-Yang He, Yu-Fen Zhao, Yan-Mei Li*.STING and TLR7/8 agonists-based nanovaccines for synergistic antitumor immune activation. Nano Res, 2022, 15, 6328.
13.Yun-Yi Luo, Jun-Jun Wu, Yan-Mei Li*.Regulation of Liquid-Liquid Phase Separation with Focus on Post-Translational Modifications. Chem Commun, 2021, 57: 13275-13287.
14.Hong-Guo Hu, Jun-Jun Wu, Bo-Dou Zhang, Wen-Hao Li, Yan-Mei Li*. Pam3CSK4-CDGSF Augments Antitumor Immunotherapy by Synergistically Activating TLR1/2 and STING. Bioconjug Chem, 2020, 31:2499-2503.
15.Lang Zhao, Jun-Jun Wu, Yan-Mei Li*. Poly(ADP-ribose): the structure and the synthesis. Arkivoc, 2020, iv:65-88.
16.Lang Zhao, Shao-Hua Zhuo, Tian-Yang Wang, Jun-Jun Wu, Jing-Yun Su, Wen-Hao Li, Bo-Dou Zhang and Yan-Mei Li*. Cyclic Dinucleotide Self-Assembled Nanoparticles as a Carrier-Free Delivery Platform for STING-Mediated Cancer Immunotherapy. CCS Chem., 2023, doi: 10.31635/ccschem.023.202302751.
17.Bo-Dou Zhang, Xi Chen, Jing-Yun Su, Shao-Hua Zhuo, Lang Zhao, Jun-Jun Wu, Wen-Hao Li, Tian-Yang Wang, Ling Liu, Tao Yang, Li-Jun Yang, Yu-Fen Zhao &Yan-Mei Li*. Rationally designed anti-autophagy nanosystems for reversing the immunosuppressive network in the tumor environment.Nanomedicine, 2025, 1, 12.
18.Hong-Guo Hu, Pu-Guang Chen, Guanyu Wang, Jun-Jun Wu, Bo-Dou Zhang, Wen-Hao Li, Rebecca L Davis*, Yan-Mei Li*. Regulation of Immune Activation by Optical Control of TLR1/2 Heterodimerization. Chembiochem, 2020, 21:1150-1154.
19.Zhan-Yi Sun, Pu-Guang Chen, Yan-Fang Liu, Bo-Dou Zhang, Jun-Jun Wu, Yong-Xiang Chen, Yu-Fen Zhao, Yan-Mei Li*.Multi-component self-assembled anti-tumor nano-vaccines based on MUC1 glycopeptides. Chem Commun, 2016, 52:7572-7575.
20.Pu-Guang Chen, Hong-Guo Hu, Zhan-Yi Sun, Qian-Qian Li, Bo-Dou Zhang, Jun-Jun Wu, Wen-Hao Li, Yu-Fen Zhao, Yong-Xiang Chen, Yan-Mei Li*. Fully Synthetic Invariant NKT Cell-Dependent Self-Adjuvanting Antitumor Vaccines Eliciting Potent Immune Response in Mice. Mol Pharm, 2020, 17:417-425.
21.Zhan-Yi Sun, Pu-Guang Chen, Yan-Fang Liu, Lei Shi, Bo-Dou Zhang, Jun-Jun Wu, Yu-Fen Zhao, Yong-Xiang Chen, Yan-Mei Li*. Self-Assembled Nano-Immunostimulant for Synergistic Immune Activation. Chembiochem,2017, 18:1721-1729.
六、授权专利
1.吴军军，欧阳松应，范陈媛，陈冠杰，2024，一种疫苗佐剂体系及其在新冠和猴痘病毒疫苗中的应用，ZL202211124097.8，中国；
2.李艳梅，吴军军，张伯斗，胡洪果，李文浩，赵朗，陈永湘，2022，新型STING激动剂及其制备方法和应用，ZL202010411675.0，中国；
3.李艳梅，吴军军，陈永湘，2022，新型疫苗佐剂及其在新冠肺炎疫苗和其他疫苗中的应用，ZL202010663965.4，中国。
七、联系方式
通讯地址：福建省福州市福建师范大学旗山校区生命科学学院理工楼11#408（邮编350117）
E-mail：junwu@fjnu.edu.cn