李达谅
一、个人简介
李达谅，男，福建泉州人，教授，博导，福建师范大学生命科学学院中心实验室主任，福建省生物医学学会常务理事，福建省健康学会理事。1996-2005，中科大本硕博连读；2005-2007，中科院上海有机所（博士后）；2007-2014，美国得州大学西南医学中心（博士后）；2014-至今，福建师范大学生科院。
二、研究方向和领域
小分子荧光探针合成探索及其在生物信号分子传导研究、食品安全检测以及功能性食品的活性成分评价；应用化学或生物探针研究免疫细胞的信号通路；天然产物的提取纯化及其在免疫生物学中的免疫调控研究；
三、主要科研项目
1、福建省科技厅引导性项目:科技特派团服务三明市明溪县生物医药重点产业链小核酸药物制造产业专项（2024-09 至 2027-09, 2024N0056, 100万元, 在研）—— 主持
2、福建省科技厅科技创新联合资金项目：通关藤提取物通过调节TAMs极化抑制肝癌干细胞特性的机制研究及其活性成分鉴定（2024-01 至 2026-12, 2023Y9415，50万元, 在研）——共同主持
3、2022年海洋经济发展专项资金项目：海洋生物质量安全快检核心技术开发与应用示范（202201-202312，FJHJF-L-2022-8，80万专项支持，已完成）——主持
4、福建省自然科学基金：新型活性无机硫物种荧光探针(Reactive Inorganic Sulfur Species，RISSs)的合成及其在细胞信号传导中的探索（202111-202410，2021J01205）——主持
5、福建省自然科学基金：应用于胰岛细胞信号研究的高分辨显微成像技术（201604-201903，2016J01143，已结题）——主持
6、福建师范大学校创新团队“基于天然免疫的化学免疫学研究”（IRTL1703，2017-2021，已结题）——主持
另主持教育部留学归国人员科研启动基金一项（已结题）；参与国家自然科学基金面上一项（烷基过氧酰化合物--烯烃炔烃的新型烷基化试剂，201721672213，第二，已结题）；曾参与国家自然科学基金重点项目（环肽类天然产物的合成和作用机制演技，20632050，排名第三，已结题）一项。
四、主要获奖成果
获得2016年福建省引进高层次人才（国外C类）；2023年福建省级高层次人才（C类）
五、代表性论著与专利
1. Ultrasensitive and Specific Fluorescent Probe towards Sulfites to Monitor Its Residue in the Traditional Herbs, Talanta, 297 (2026)， Part B，128760. https://doi.org/10.1016/j.talanta.2025.128760
2. Complementary Assay to Determine Residual Sulfite of the Preserved Fruit with Ratiometric Probe, Journal of Food Composition and Analysis, 147 (2025), 108034. https://doi.org/10.1016/j.jfca.2025.108034
3. Tanshinone IIA alleviates myocarditis in Trex1-D18N lupus-like mice by inhibiting the interaction between STING and SEC24C, International Immunopharmacology, 156 (2025) 114659. https://doi.org/10.1016/j.intimp.2025.114659
4. Peroxynitrite as Biomarker to Evaluate the Rehabilitation of Cisplatin in the Resistant Cells with miR-125a-5p by Using Fluorescent Assay, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 330 (2025) 125663. https://doi.org/10.1016/j.saa.2024.125663
5. Recent applications of the Sonogashira reaction in the synthesis of drugs and their derivatives: a review, Applied Organometallic Chemistry，2025; 39:e7932. https://doi.org/10.1002/aoc.7932
6. Interpret the Potential Role of Zinc against Oxidative Stress in Inflammation with a Practical Fluorescent Assay, Bioorganic Chemistry, Volume 153, December 2024, 107886. https://doi.org/10.1016/j.bioorg.2024.107886
7. Significance of Programmed Cell Death Pathways in Neurodegenerative Diseases, Int. J. Mol. Sci. 2024, 25, 9947. https://doi.org/10.3390/ijms25189947.
8. Accurate and rapid mercury susceptibility detection in aquatic samples using fluorescent probe integrated rhodamine with pyridyl isothiocyanate, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 323 (2024) 124886. https://doi.org/10.1016/j.saa.2024.124886
9. Comprehensive insights into fluorescent probes for the determination nitric oxide for diseases diagnosis , Bioorganic Chemistry, 150 (2024), 107505. https://doi.org/10.1016/j.bioorg.2024.107505
10. Recent Progress of Near-infrared Fluorescent Probes in the Determination of Reactive Oxygen Species for Disease Diagnosis, Talanta, 268 (2024), 125264. https://doi.org/10.1016/j.talanta.2023.125264
11. DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1−/− mice，Biomedicine & Pharmacotherapy, 2023, 165 (2023) 115188.
12. Recent Progress of Fluorescent Probes toward Heavy Metal Determinations for Food Safety: A Review, Molecules, 2023, 28, 5689.
13. 李达谅，王博，邓威力, 一种反应性罗丹明B衍生物荧光探针及其制备方法和应用, ZL 2021 1 0988516.1
14. 李达谅，张兰兰，邓威力，余舒婷，一种锌离子近红外荧光探针及其制备方法与应用，ZL202111444222.9
15. Synthesis of unsymmetrically tetrasubstituted pyrroles and studies of AIEE in pyrrolo[1,2- a ] pyrimidine derivatives, Chemical Sciences, 2022, 13, 5667 – 5673.
16. Rhodol-based fluorescent probes used for fast response toward ClO- and delayed determination of H2O2 in living cells, Synthesis, 2022, 54(14): 3282-3288.
17. Iron-catalyzed Asymmetric Decarboxylative Azidation, Org. lett., 2021, 23, 22, 8847-8851.
18. Celastrol Ameliorates Autoimmune Disorders in Trex1-deficient Mice, Biochemical Pharmacology, Volume 178, August 2020, 114090
19. The ratiometric fluorescent probes for monitoring the reactive inorganic sulfur species (RISS) signal in the living cell, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, https://doi.org/10.1016/j.saa.2020.118141. 231 (2020) 118141.
20. Iron-Catalyzed Oxyalkylation of Terminal Alkynes with Alkyl Iodides. Org. lett. 2019, 21, 261-265.
21. Imaging dynamic insulin release using a fluorescent zinc indicator for monitoring induced exocytotic release (ZIMIR), Proc. Natl. Acad. Sci. USA, 2011, 108 (52), 21063-21068.
六、联系方式
电话：13696871978
邮箱：daliangli@@fjnu.edu.cn; lidlbhl@163.com