沈阳坤
一、个人简介
沈阳坤博士，福建省高层次人才C类，福建省免疫学会青年委员会常务委员，福建省免疫学会肿瘤免疫与生物治疗专业委员会委员。长期从事天然免疫通路cGAS-STING介导的抗肿瘤免疫应答研究，干细胞及免疫细胞对肿瘤的治疗、以及CRISPR/Cas9基因编辑技术的改造及应用。先后以主要完成人的身份参与国家自然科学基金重点项目2项、国家自然科学基金应急管理项目1项；主持/参与福建省自然科学基金、福建省科技创新联合基金等项目10余项。相关工作在Trends in pharmacological sciences、Journal of Translational Medicine、CMLS、IJBM等期刊发表SCI文章/专著20余篇，总引用次数超过200次，多次受邀编写Springer Nature 出版集团旗下的Methods in Molecular Biology系列丛书。授权国家发明专利2项，正在审查3项。
近年来，带领学生参加中国国际大学生创新大赛、全国大学生互联网＋创新创业大赛、全国大学生生命科学竞赛等比赛，多次获得国家级奖项（国家级金奖1项、银奖1项、铜奖1项和三等奖1项）和省级奖项（福建省金奖2项、银奖2项、铜奖1项和二等奖1项），个人获得福建省优秀创新创业导师奖。
二、研究方向和领域
1.天然免疫通路cGAS-STING介导的抗病毒及抗肿瘤免疫应答研究；
2.干细胞对代谢以及炎症性疾病的治疗研究；
3.免疫细胞（CAR-T、TILs等）在肿瘤治疗中的耐药机制及应用研究；
4.新型肿瘤治疗药物研究；
5.CRISPR/Cas9基因编辑技术的改造及应用。
三、代表性论著
近三年文章：
1.Yi Ye, Jinyun Wu, Tao Sun, Minghong Huang, Jiaping Pan, Danjing Hu, Keying Chen, Dawei Wang, Chenxi Wang, Yangkun Shen, Qi Chen, Baolin Huang. Immunomodulating red blood cell coating for mitigation of foreign body reactions. Engineered Regeneration. 2025, 6, 218-229.
2. Lin, Y.; Luo, S.; Wei, J.; Lin, S.; Wang, D.; Zhao, X.; Feng, Z.; Shen, Y*.; Chen, Q. Limitations of CAR-T-Cell Therapy in Hematologic Malignancies: Focusing on Antigen Escape and T-Cell Dysfunction. Int. J. Mol. Sci. 2025, 26, 9669.
3.Yangkun Shen, Hucheng Zhang, Mengzhou Xue†, Chunfu Zheng†, and Qi Chen†.HSV-1 as a Gene Delivery Platform for Cancer Gene Therapy.Trends in pharmacological sciences, 2025, 3.
4.Zhihua Feng†, Xinyan He†, Minhua Lin†, Heng Zhao†, Yao Chen, Jianghua Chen, Zhaolong Li, Yangkun Shen*, Jianxin Chen*, Qi Chen*. Genome-wide CRISPR/Cas9 screening identified ALG5, ALG6, NF2 and FUT8 as key host factors for Transmissible Gastroenteritis Virus infection. IJBM, 2025, 5.
5.Feng Z, Fu Y, Yang S, Zhao H, Lin M, Liu C, Huang W, He X, Chen Y, Chen J, Shen Y†, Li Z†,Chen Q†. Siglec-15 is a putative receptor for porcine epidemic diarrhea virus infection. Cell Mol Life Sci. 2025, 82(1):136.
6.Zhijian Huang, Xiangqian Zhao, Zirong Jiang, Xiaoting Qiu, Xinhao Sun, Dawei Wang, Hucheng Zhang, Qi Chen, Ruirong Tan, and Yangkun Shen†. IP6K2 mutations as a novel mechanism of resistance to oncolytic virus therapy. JTransl Med 23, 311 (2025).
7. Chenxi Wang, Xiangqian Zhao, Dawei Wang, Jinyun Wu, Jizhen Lin, Weiwei Huang, Yangkun Shen† and Qi Chen†. Analysis of prognostic factors and nomogram construction for postoperative survival of triple-negative breast cancer. Frontiers in Immunology, 2025 Apr 7;16:1561563.
8.Feng Z, Zhao H, Li Z, Lin M, Huang W, Liu C, Shen Y†, Chen Q†. The Infectivity and Pathogenicity Characteristics of a Recombinant Porcine Epidemic Diarrhea Virus, CHFJFQ. Viruses. 2025, 17(3):401.
9.Yangkun Shen, Xiangqian Zhao, Lizhu Chen, Xin Wang, Dawei Wang, Hucheng Zhang, Zuda Zheng, Weiwei Huang, Chunfu Zheng, Yu Chen, Chuanben Chen, Qi Chen. A modified HSV-1 oncolytic virus reconciles antiviral and antitumor immunity via promoting IFNβ expression and inhibiting PKR. IJBM, 2024, 274（2），133297.
10.Guohao Li, Xiangqian Zhao, Zuda Zheng, Hucheng Zhang, Yundi Wu, Yangkun Shen* and Qi Chen*.cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors. CMLS, 2024, 81:149.
11.Huang W, Wang C, Shen Y, Chen Q, Huang Z, Liu J, Lin X, Wang L, Wu F, Chen X, Li N, Hong Y, Chen M, Li J, Huang C. A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer. BMC Cancer. 2024, 24(1):39.
12.Guijin Tang, Dawei Wang, Xiangqian Zhao, Zhihua Feng, Qi Chen *, Yangkun Shen*. The Dilemma of HSV-1 Oncolytic Virus Delivery: The Method Choice and Hurdles. IJMS, 2023
13.Dawei Wang, Heng Zhao, Yangkun Shen* and Qi Chen*. A Variety of Nucleic Acid Species Are Sensed by cGAS, Implications for Its Diverse Functions [J]. Frontiers in Immunology, 2022,344.
14.Changhua Zhuo*, Qiang Ruan, Xiangqian Zhao, Yangkun Shen* and Ruirong Lin.CXCL1 Promotes Colon Cancer Progression Through Activation of NF-κB/P300 Signaling Pathway.Biology Direct, 2022, 17:34.
15.Chiang ZC, Fang S, Shen YK, Cui D, Weng H, Wang D, Zhao Y, Lin J, Chen Q. Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo. Front Oncol. 2022; 12:857927.
专著：
1.Shen Y, Zhao X, Zheng C, Chen Q. CRISPR-Mediated Construction of Gene-Knockout Mice for Investigating Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:61-74.
2.Shen Y, Feng Z, Zheng C, Chen Q. CRISPR-Mediated Library Screening of Gene-Knockout Cell Lines for Investigating Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:51-60.
3.Feng Z, Shen Y, Zheng C, Chen Q. CRISPR-Mediated Viral Gene Knockout to Investigate Viral Evasion of Antiviral Innate Immunity. Methods Mol Biol. 2025; 2854:41-50.
四、联系方式
E-mail：shenyk@fjnu.edu.cn