李力
福建师范大学，生命科学学院，教授，博士生导师
教育经历：
2004/04-2008/12，上海交通大学，生命科学与技术学院，博士
1998/09-2001/07，福建农林大学，植物保护系，硕士
1994/09-1998/07，厦门大学，生物系，本科
科研工作经历：
1. 2008/12-至今 福建师范大学，生命科学学院，讲师、副教授和教授
2. 2015/03-2017/02 加州大学洛杉矶分校，化学与生物工程系，访问学者
3. 2010/10-2011/10 加州大学洛杉矶分校，化学与生物工程系，博士后
社会兼职:
中国生物化学与分子生物学会理事；福建省生物化学与分子生物学会副理事长；中国微生物学会分子微生物学及生物工程专业委员会委员；中国菌物学会药用真菌专业委员会委员；福建省微生物学会理事
主要研究方向：
1. 微生物天然产物的发现与基因组挖掘：我们利用真菌或放线菌基因组的信息，通过基因激活技术和异源表达手段，挖掘出新颖天然产物；
2. 工业微生物的基因工程与代谢工程：我们的研究包括菌种的选育、基因工程和代谢工程的改造以实现从实验室到生产的衔接，产品包括酶和代谢产物。
招生方向（欢迎各位同学报考）：
博士后：生物学/化学方向；博士研究生：微生物学/生物化学专业；硕士研究生：生物学/生物工程专业（学术学位）、生物与医药（专业学位）
主持科研项目：
（1）国家重点研发计划合成生物学专项课题，2021YFA0910501，先导化合物生物合成路径的解析及骨架相关元件库的构建，2021/12-2026/11
（2）国家自然科学基金面上项目，32170069，一种靶向AHAS的真菌天然除草化合物的发现及作用机制，2022/01- 2025/12
（3）国家自然科学基金面上项目，31870039，进化树指导下真菌新颖聚酮-非核糖体肽化合物发现与生物合成研究，2019/01-2022/12
（4）国家自然科学基金青年项目，31000038，米多霉素的生化途径和基因改造，2010/01-2013/12
（5）福建省科技厅高校产学研联合创新（校校企）项目，基于生物被膜制备新型生物农药的关键技术及产品研发，2020N5014，2020/12-2023/12
（6）福建省发改委科技项目，微生物发酵法生产辅酶Q10关键技术的研究开发，2010/01-2012/12
（7）福建省自然科学基金面上项目，2021J01173，红曲菌天然活性物质的挖掘及无毒生产菌株的构建，2021/11-2024/11
（8）福建省自然科学基金面上项目，2018J01727，蛹虫草天然活性产物的基因组挖掘，2018/04-2021/03
（9）福建省自然科学基金青年项目，2010J05057，单组分高效低毒脱羟甲基米多霉素的组合生物合成，2010/06-2013/05
（10）福建省第五轮卫生教育联合攻关计划项目，基于代谢组学分析肠道微生物对过敏性鼻炎发生的影响，2019/12-2022/12
主要研究论文：
1.Xiao, J.#, W. Lin#, X. Chen, H. Yu, C. Chen, Q. Li, F. Cai, H. Zhang, H. Chen, M. Zhang*, Y.J. Zhou* and L. Li*, Toward sustainable food preservatives: high-level production of sorbic acid in engineered Saccharomyces cerevisiae. Nature Communications, 2026.https://doi.org/10.1038/s41467-026-72163-8
2.Lin, W#., W. Lin#, L. Yang, C. Zhang, X. Li, J. Xiao, X. Chen, F. Cai, C. Chen, M. Zhang*, Y. Zhang* and L. Li*, Characterization of a novel Dye-Decolorizing peroxidase from Brevibacillus agri and its application in detoxification of textile industry wastewater. Bioresource Technology, 2026. 440: p. 133430.
3.Huang, L., L. Wu, L. Zhao, K. Chen, R. Lin, L. Li, Y. Liu* and H. Chen*, Structural and Anti-Inflammatory Activity of Ultrasonic Treating Polysaccharide Extracted From Tremella fuciformis Stem Byproducts. Food Frontiers, 2026. 7(1): p. e70200.
4.Gao, Y.-L., W. Chen, J.-J. Zhang, P.-L. Li, L. Li* and H. Zhang*, Elucidation of the pramanicin biosynthetic pathway reveals a DUF2306 family membrane protein involved in terminal epoxidation. Frontiers in Microbiology, 2026. 17: p. 1765828.
5.Chen, X., H. Wu, H. Shu, H. Yu, F. Cai, J. Xiao, W. Lin, Y. Shi, M. Zhang, Q. Li, H. Zhang*, W. Chen* and L. Li*, Bioactive metabolites from Samsoniella sp. KY1174: isolation, characterization, and cytotoxicity against cancer cell lines. Natural Product Research, 2026: p. 1-6.
6.Cai, F., X. Chen, W. Chen, J. Chen, M. Zhang, Q. Li, H. Zhang, L. Li* and H. Zhang*, Two new polyketide-amino acid hybrids with antibacterial activities from Cordyceps cicadae. Natural Product Research, 2026. 40(8): p. 2007-2013.
7.Liu, H., S.-Y. He, J.-H. Lu, Y.-L. Lin, J.-M. Lin, J.-W. Han, L. Li, M.-L. Zhang, J.-H. Wang* and M.-M. Liu*, A user-friendly 3D-printed paper analysis platform with integrated STAB/MWCNTs electrochemical sensor for on-site methotrexate monitoring in serum. Sensors and Actuators B: Chemical, 2026. 460: p. 139887.
8.Lin, W., Y.-L. Gao, K. Sang, S.-T. Wang, J.-B. Xiao, H.-Y. Yu, X.-T. Chen, C. Chen, F. Cai, M.-L. Zhang*, M.-C. Tang* and L. Li*, Discovery and Biosynthesis of Cytotoxic Myroverols: A Phenalenone Scaffold Constructed by a Fungal Highly Reducing Polyketide Synthase and a Cytochrome P450. Organic Letters, 2025. 27(49): p. 13661-13666.
9.Yan, P., H. Zhang* and L. Li*, Recent progress in macrocyclic trichothecene research: structures, biosynthetic pathways, and biological activities. Archives of Microbiology, 2025. 207(10): p. 249.
10.Lin, W., J.-b. Xiao, X.-t. Chen, H.-y. Yu, F. Cai, C. Chen, P.-w. Yan, M.-l. Zhang* and L. Li*, Three New Pyrones With Antifungal Activity From Myrothecium verrucaria ACCC 38039. Chemistry & Biodiversity, 2025. 22(12): p. e01554.
11.Zhao, L., X. Yang, P. Ye, Z. Lan, J. Cheng, L. Li, J. Wu, W. Xu and H. Chen*, Prebiotic effects and functional insights into gut microbiota mediated by Qingke β-glucan of different molecular weights in vitro fermentation. Bioactive Carbohydrates and Dietary Fibre, 2025. 34: p. 100488.
12.Chen, W.-P., W. Lin, W. Chen, S.-z. Chen, J.-B. Xiao, X.-T. Chen, C. Chen, F. Cai, M.-L. Zhang, Q. Li, H.-D. Zhang, L. Li* and H. Zhang*, Heterologous Expression of the Fellutanine Biosynthetic Gene Cluster and Characterization of the Dual Prenylation of cyclo(l-Trp-l-Trp) by a Single DMATS Enzyme. Journal of Natural Products, 2025. 88(5): p. 1111-1119.
13.Chen, S., W. Lin, Y. Zhang, F. Cai, W. Lin, J. Xiao, X. Chen, Q. Li, H. Zhang, M. Zhang* and L. Li*, Enhancing ergothioneine production in Saccharomyces cerevisiae via protein fusion technology and gene integration optimization. Food Bioscience, 2025. 68: p. 106745.
14.Chen, H.*, X. Shen, J. Lin, Q. Huang, L. Zhao, R. Zhu, L. Li, Z. Liu and C. Zhao*, Microplastics in crustaceans imposing potential risk on human health: transferring, degradation, synergy, and metabolism. Critical Reviews in Food Science and Nutrition, 2025: p. 1-21.
15.Chen, C., Y. Shi, H. Ding, L. Yu, W. Lin, J. Xiao, H. Zhang, Q. Li, M. Zhang* and L. Li*, Heterologous expression of Pyrenocine A from Colletotrichum gloeosporioides CGMCC 3.17371. Natural Product Research, 2025: p. 1-9.
16.Cai, F., W. Xie, H. Yu, X. Chen, W. Lin, J. Xiao, C. Chen, M. Zhang, Q. Li, H. Zhang, H. Zhang* and L. Li*, Two new amplisins with antibacterial activities from Akanthomyces attenuatus. Natural Product Research, 2025: p. 1-8.
17.Li, Q., Y. Zheng, L. Guo, Y. Xiao, H. Li, P. Yang, L. Xia, X. Liu, Z. Chen, L. Li and H. Zhang*, Microbial Degradation of Tetracycline Antibiotics: Mechanisms and Environmental Implications. Journal of Agricultural and Food Chemistry, 2024. 72(24): p. 13523-13536.
18.Gao, Y., L. Liao, Y. Xu, J. Huang*, J. Gao* and L. Li*, Bioinformatic Approaches Identify Hybrid Antibiotics against Tuberculosis via d-Amino Acid-Activating Adenylation Domains from Cordyceps militaris. Journal of Natural Products, 2024. 87(8): p. 2110-2119.
19.Ullah, I., E. Khan, Z.J. Zhang, S.C. Xiang*, C. Chen and L. Li, Synthesis, crystal growth and supramolecular chemistry of 4-dimethylaminopyridinium salts of benzoates and a phenolate ion. Zeitschrift für Physikalische Chemie-International Journal of Research in Physical Chemistry and Chemical Physics, 2023. 237(9): p. 1381-1408.
20.Chen, Z., S. He, Y. Wei, Y. Liu, Q. Xu, X. Lin, C. Chen, W. Lin, Y. Wang, L. Li* and Y. Xu*, Fecal and serum metabolomic signatures and gut microbiota characteristics of allergic rhinitis mice model. Frontiers in Cellular and Infection Microbiology, 2023. 13. p. 1150043.
21.Zhang, M., Y. Gao, C. Yu, J. Wang, K. Weng, Q. Li, Y. He, Z. Guo, H. Zhang, J. Huang and L. Li*, Transcriptome analysis of malate-induced Schizochytrium sp. FJU-512 reveals a novel pathway for biosynthesis of docosahexaenoic acid with enhanced expression of genes responsible for acetyl-CoA and NADPH accumulation. Frontiers in Microbiology, 2022. 13. p. 1006138.
22.Yu, C., L. Chen, Y.L. Gao, J. Liu, P.L. Li, M.L. Zhang, Q. Li, H.D. Zhang, M.C. Tang* and L. Li*, Discovery and biosynthesis of macrophasetins from the plant pathogen fungus Macrophomina phaseolina. Frontiers in Microbiology, 2022. 13. 1056392.
23.Gao, Y.-L., C. Yu and L. Li*, Heterologous expression of a natural product biosynthetic gene cluster from Cordyceps militaris. the Journal of Antibiotics, 2022. 75(1): p. 16-20.
24.Chen, Z., Q. Xu, Y. Liu, Y. Wei, S. He, W. Lin, Y. Wang, L. Li* and Y. Xu*, Vancomycin-induced gut microbiota dysbiosis aggravates allergic rhinitis in mice by altered short-chain fatty acids.Frontiers in Microbiology, 2022. 13. p. 1002084.
25.Zhang, M., H. Zhang, Q. Li, Y. Gao, L. Guo, L. He, S. Zang, X. Guo, J. Huang and L. Li*, Structural Insights into the Trans-Acting Enoyl Reductase in the Biosynthesis of Long-Chain Polyunsaturated Fatty Acids in Shewanella piezotolerans. Journal of Agricultural and Food Chemistry, 2021. 69(7): p. 2316-2324.
26.Gao, Y.-L., M.-L. Zhang, X. Wang, H.-D. Zhang, J.-Z. Huang and L. Li*, Isolation and characterization of a new cytotoxic polyketide–amino acid hybrid from Thermothelomyces thermophilus ATCC 42464. Natural Product Research, 2021. 35(11): p. 1792-1798.
27.Gao, Y., M. Xie, C. Yu, M. Zhang, J. Huang, Q. Li, H. Zhang and L. Li*, Heterologous Expression of Macrollins from Phytopathogenic Macrophomina phaseolina Revealed a Cytochrome P450 Mono-oxygenase in the Biosynthesis of β-Hydroxyl Tetramic Acid. Journal of Agricultural and Food Chemistry, 2021. 69(50): p. 15175-15183.
28.Wang, X., Y.-L. Gao, M.-L. Zhang, H.-D. Zhang, J.-Z. Huang and L. Li*, Genome mining and biosynthesis of the Acyl-CoA:cholesterol acyltransferase inhibitor beauveriolide I and III in Cordyceps militaris. Journal of Biotechnology, 2020. 309: p. 85-91.
29.Zhang, Y., Y. Zhang, M. Li, L. Li*, X. Tang* and J. Gao*, Homogenization significantly enhances growth of macroalga Saccharina japonica female gametophytes. Algal Research, 2019. 43: p. 101640.
30.Li, L.#, M.-C. Tang#, S. Tang, S. Gao, S. Soliman, L. Hang, W. Xu, T. Ye, K. Watanabe and Y. Tang*, Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids. Journal of the American Chemical Society, 2018. 140(6): p. 2067-2071.
31.Li, L., J. Huang* and Y. Lin*, Snake Venoms in Cancer Therapy: Past, Present and Future. Toxins, 2018. 10(9). p. 346.
32.Zou, Y., M. Garcia-Borràs, M.C. Tang, Y. Hirayama, D.H. Li, L. Li, K. Watanabe, K.N. Houk* and Y. Tang*, Enzyme-catalyzed cationic epoxide rearrangements in quinolone alkaloid biosynthesis. Nature Chemical Biology, 2017. 13(3): p. 325-332.
33.Li, L., P. Yu, M.-C. Tang, Y. Zou, S.-S. Gao, Y.-S. Hung, M. Zhao, K. Watanabe, K.N. Houk and Y. Tang*, Biochemical Characterization of a Eukaryotic Decalin-Forming Diels–Alderase. Journal of the American Chemical Society, 2016. 138(49): p. 15837-15840.
34.Bond, C.#, Y. Tang* and L. Li#, Saccharomyces cerevisiae as a tool for mining, studying and engineering fungal polyketide synthases. Fungal Genetics and Biology, 2016. 89: p. 52-61.
35.Yu, G., L. Li, X. Liu, G. Liu, Z. Deng, M.T. Zabriskie, M. Jiang and X. He, The standalone aminopeptidase PepN catalyzes the maturation of blasticidin S from leucylblasticidin S. Scientific Reports, 2015. 5(1): p. 17641.
36.Han, T., M. Yamada-Mabuchi, G. Zhao, L. Li, G. liu, H.-Y. Ou, Z. Deng, Y. Zheng and X. He*, Recognition and cleavage of 5-methylcytosine DNA by bacterial SRA-HNH proteins. Nucleic Acids Research, 2015. 43(2): p. 1147-1159.
37.Li, L., P. Wang and Y. Tang*, C-glycosylation of anhydrotetracycline scaffold with SsfS6 from the SF2575 biosynthetic pathway. the Journal of Antibiotics, 2014. 67(1): p. 65-70.
38.Li, L., J. Wu, Z. Deng, T.M. Zabriskie and X. He, Streptomyces lividans Blasticidin S Deaminase and Its Application in Engineering a Blasticidin S-Producing Strain for Ease of Genetic Manipulation. Applied and Environmental Microbiology, 2013. 79(7): p. 2349.
39.Wu, J., Li, L., Z. Deng, T.M. Zabriskie and X. He, Analysis of the Mildiomycin Biosynthesis Gene Cluster in Streptoverticillum remofaciens ZJU5119 and Characterization of MilC, a Hydroxymethyl cytosyl-glucuronic Acid Synthase. Chembiochem, 2012. 13(11): p. 1613-1621.
40.Liu, G., H.-Y. Ou, T. Wang, L. Li, H. Tan, X. Zhou, K. Rajakumar, Z. Deng and X. He, Cleavage of Phosphorothioated DNA and Methylated DNA by the Type IV Restriction Endonuclease ScoMcrA. PLoS Genetics, 2010. 6(12): p. e1001253.
41.Li, L., Z. Xu, X. Xu, J. Wu, Y. Zhang, X. He, T.M. Zabriskie and Z. Deng, The Mildiomycin Biosynthesis: Initial Steps for Sequential Generation of 5-Hydroxymethylcytidine 5′-Monophosphate and 5-Hydroxymethylcytosine in Streptoverticillium rimofaciens ZJU5119. Chembiochem, 2008. 9(8): p. 1286-1294.