陈涛涛副教授/硕士生导师
一、个人简介
2015.09 至 2019.12 厦门大学 博士 生物化学与分子生物学
2011.09 至 2014.07 福州大学 硕士 食品科学
2007.09 至 2011.07 海南大学 学士 食品科学与工程
科研与学术工作经历：
2025-01至今 福建师范大学，生命科学学院，副教授
2023-12至2024-12 福建师范大学，生命科学学院，讲 师
2020-08至2023-10 福建师范大学，生命科学学院，博士后
本团队长期聚焦于病原菌感染与宿主免疫互作的分子机制研究，综合运用高通量组学分析（蛋白质组学、蛋白质修饰组学及液相色谱-质谱联用技术）、生物化学、细胞生物学及结构生物学手段（核磁共振 NMR、X 射线晶体衍射和冷冻电镜技术），系统解析病原体效应蛋白的生物学功能及其与宿主相互作用的动态调控网络，多维度揭示病原体侵袭过程中的致病分子机制与宿主免疫应答规律，旨在阐明病原体-宿主互作的关键分子事件，为开发新型抗菌药物和免疫调节剂提供具有临床应用价值的候选靶点。至今，已在国内外期刊上发表论文 20 余篇，包括 Nature Chemical Biology、Science Advances、Nature Communications等 Nature/Science 子刊论文。主持国家自然科学基金、中国博士后科学基金及福建省自然科学基金项目，兼任福建省遗传学会理事及Health & Metabolism（HM）、Frontiers in Bioscience-Landmark（FBL）期刊杂志青年编委。
三、主要科研项目
1.国家自然科学基金委员会，面上项目，82572582，嗜肺军团菌效应蛋白 Lpg2832抑制宿主细胞铁死亡的分子机制研究，2026-01至2029-12，49万元，主持
2.福建省自然科学基金会，面上项目，2025J01639. 嗜肺军团菌效应蛋白Lpg2832抑制宿主铁死亡的分子机制，2025-11 至 2028-10, 10万元，主持
3.福建师范大学青年英才引进科研启动基金，2024-2032, 50万元，主持
4.中国博士后科学基金会，面上项目，2020M682067，嗜肺军团菌效应蛋白AnkD的结构及调控宿主细胞脂滴的分子机制，2020-01至2023-10，8万元，主持
四、近五年发表论文（# 共同第一作者；* 通讯作者）
1.Tao-Tao Chen#, Qiuhua Lu#, Si-Ru Zheng#, Jiaqi Fu#, Lina Kang, Juhong Wu, Jiwei Luo, Jiangyang Tong, Siying Li, Xiangliang Li, Shan Li, Jinyu Li, Zhao-Qing Luo*, Songying Ouyang*. Structural and mechanism of a bacterial actin-dependent phosphoryl-AMPylase. Nature Chemical Biology. 2025.
2.Chunlin He, Chuang Li, Yao Liu, Tao-Tao Chen, Chunxiu Li, Xiao Chu, Shuxin Liu, Lidong Wang, Yong Zhang, Songying Ouyang, Jiaqi Fu, Lei Song*, Zhao-Qing Luo*. Modulation of host ATP levels by secreted bacterial effectors. Nature Communications. 2025.
3.Jiaqi Fu#,Siying Li#, Hongxin Guan#, Chuang Li#, Yan-Bo Zhao#, Tao-Tao Chen, Wei Xian, Zhengrui Zhang, Yao Liu, Qingtian Guan, Jingting Wang, Qiuhua Lu, Lina Kang, Si-Ru Zheng, Jinyu Li, Shoujing Cao, Chittaranjan Das, Xiaoyun Liu*, Lei Song*, Songying Ouyang*, Zhao-Qing Luo*. Legionella Maintains Host Cell Ubiquitin Homeostasis by Effectors with Unique Catalytic Mechanisms. Nature Communications. 2024.
4.Yanyun Guan#, Jingjie Chen#, Hongxin Guan, Tao-Tao Chen, Yan Teng, Zuyun Wei, Zekai Li, Songying Ouyang*, Xinhua Chen*. Structural and Functional Characterization of a Fish Type I Subgroup D IFN Reveals Its Binding to Receptors. The Journal of Immunology. 2024.
5.Tao-Tao Chen#, Si-Ru Zheng#, Li Tian#, Sunliang Lv, Wenhong Zhong, Xiangliang Li, Dandan Zhang, Xuexing Zheng*, Songying Ouyan*. Structural basis for the action mechanism of Legionella glycosyltransferase,Small Structures, 2023.
6.Tao-Tao Chen#, Yanling Lin#, Shijun Zhang#, Shuxin Liu, Lei Song, Wenhong Zhong, Zhao-Qing Luo, Aidong Han. Atypical Legionella GTPase effector hijacks host vesicular transport factor p115 to regulate host lipid droplet.Science Advances, 2022.
7.Yan-Bo Zhao#, Meng-Xi Liu#, Tao-Tao Chen#, Xiaomin Ma, Ze-Kai Li, Zichao Zheng, Si-Ru Zheng, Lifei Chen, You-Zhi Li, Li-Rui Tang, Qi Chen, Peiyi Wang*, Songying Ouyang*. Pathogen effector AvrSr35 triggers Sr35 resistosome assembly via a direct recognition mechanism.Science Advances, 2022.
8.Tao-Tao Chen#, Yanling Lin#, Shijun Zhang, Aidong Han*, et al. Structural basis for the acetylation mechanism of the Legionella effector VipF.Acta Crystallographica Section D：Structural biology, 2022.
9.Pang W#, Lu Y#, Zhao Y#, Shen F#, Fan C, Wang Q, He W, Li Z, Chen T.T, et al. A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein.Cell Research, 2022.
10.Liu M.X, Zhao Y.B, Li Z.K, Chen T.T, et al. Assembly and purification of AvrSr35-induced Sr35 resistosome and determination of its structure by cryo-EM. STAR Protocols, 2022.
11.McCloskey A, Perri K, Chen T.T, et al. The metaeffector MesI regulates the activity of the Legionella effector SidI through direct protein-protein interactions.Microbes and Infection, 2021.
12.Chen Tao-Tao, Chen Z, Wang H.M, et al. Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective effects on hydrogen peroxide induced cell injury. Journal of Functional Foods, 2018.
五、联系方式
Tel: 15759258780 E-mail: chentaotao10@163.com