吴允昆 博士 教授 博士生导师
国家重大人才计划“青年项目”入选者
福建省引进高层次创业创新人才
电子邮件：wuyk@fjnu.edu.cn
地址：福州闽侯区福建师范大学旗山校区理工楼11#513
教育和科研简介:
本科毕业于武汉大学生命科学学院细胞生物学专业，博士毕业于美国University of Alabama at Birmingham，并进行了短期的博士后工作，曾荣获美国生物物理学会研究生科研成就奖。随后在美国HHMI / UT Southwestern Medical Center从事科研工作。2011年任中国科学院福建物质结构研究所课题组长，博士生导师，曾担任所学术委员会和学位委员会委员。2017年加入福建师范大学生命科学学院任“闽江学者”特聘教授。研究成果以第一作者或通讯作者发表在Nature 和 Nature Structural & Molecular Biology、Nature Communications和Biomaterials等杂志上，获发明专利授权十余项。曾入选国家重大人才计划“青年项目”、中国科学院“百人计划”、福建省“百人计划”等。
主要研究方向：
1）生物大分子结构、功能与应用
2）基于结构的纳米运载体和分子调控剂等药物研发
主要代表性论文：
Wu Y,Yang Y, Ye S, Jiang Y. Structure of the Intracellular Gating Ring fromthe Human High-conductance Ca2+-gated K+ Channel. Nature 2010 466(7304):393-7.
Wu Y,Sha B. Crystal structure of yeast mitochondrial outer membranetranslocon member Tom70p. Nature Structural & Molecular Biology 2006 13(7):589-93.
Wu X, Zhao Y, Zhang H, Yang W, Yang J, Sun L, Jiang M, Wang Q, Wang Q,Ye X, Zhang X, Wu Y. Mechanism of regulation of theHelicobacter pylori Cagβ ATPase by CagZ. Nature Communations. 2023 Jan30;14(1):479. doi: 10.1038/s41467-023-36218-4.
Li S, Zhao Y, ZhaoZ, Wu X, Sun L, Liu Q, Wu Y. Crystalstructure of GRAS domain of SCARECROW-LIKE 7 in Oryza sativa. Plant Cell. 2016 May;28(5):1025-34 DOI: 10.1105/tpc.16.00018 (highlighted article)
Zhang L, Zeng Z,Hu C, Bellis SL, Yang W, Su Y, Zhang X, WuY. Controlled and targeted release of antigens by intelligent shell forimproving applicability of oral vaccines. Biomaterials 2016 Jan，77:307-19.
Zhang L, Fan Y, Wu Y. Inositol based none-viral vectorsfor transgene expression in human cervical carcinoma and hepatoma cell lines. Biomaterials 35(6):2039-50.
Zhang L, Hu C,Yang W, Liu X, Wu Y. ChemicalSynthesis, Versatile Structures and Functions of Tailorable Adjuvants forOptimizing Oral Vaccination. ACS Applied Materials & Interfaces 2016 Dec 28;8(51):34933-34950. doi: 10.1021/acsami.6b10470.
Chen F, Xiao F,Zhang W, Lin C, Wu Y. Highly Stable and NIR LuminescentRu-LPMSN Hybrid Materials for Sensitive Detection of Cu2+ in Vivo.ACS Appl Mater Interfaces. 2018 Aug 15;10(32):26964-26971. doi:10.1021/acsami.8b08887.
Chen Fangman, ZhangFan, Shao Dan, Zhang Weibin, Zhen Liqin, Wang Wei, Yang Wendi, Wang Zheng, ChenJianxin, Dong Wenfei, Xiao Fangnan, Wu Yunkun. Bioreducible and traceable Ru(III) prodrug-loaded mesoporous silicananoparticles for sequentially targeted nonsmall cell lung cancer chemotherapy. Applied Materials Today, 2020, 19：100558.
Lifei Chen, Pu Chen, Shengping Li, Meiqin Jiang, Hong Zhang, LeiqingChen, Xiaojing Huang, Yayu Chen, LifangSun, Panpan Dong, Pingdong Lin, YunkunWu. Crystal Structure of the Disease-Specific Protein of Rice StripeVirus. J Agric Food Chem, 2022, 70(27):8469-8480. DOI: 10.1021/acs.jafc.2c02165
Chunhua Zhu, YayuChen, Michail N. Isupov, Littlechild A. Jennifer, Lifang Sun, Xiaodong Liu,Qianchao Wang, Hui Gong, Panpan Dong, Na Zhang, Yunkun Wu. Structural insights into a novel esterase from the EastPacific Rise and its improved thermostability by a semirational design. J Agric Food Chem, 2021, 69 (3), 1079-1090. doi: 10.1021/acs.jafc.0c06338.Epub 2021 Jan 14.
Zhang L, Yang W,Hu C, Wang Q, Wu Y. Properties and applications ofnanoparticle/microparticle conveyors with adjuvant characteristics suitable fororal vaccination. Int J Nanomedicine. 2018 May21;13:2973-2987. doi: 10.2147/IJN.S154743.
Zhang L, Bellis SL, Fan Y, Wu Y.Using Inositol as a Biocompatible Ligand for Efficient Transgene Expression. International Journal of Nanomedicine.2015:10 2871-84.
Zhang L, Hu C, FanY, Wu Y. Binary gene vectors basedon hyperbranched poly(L-lactide-co-polyglycerol) and polyethylenimine forprolonged transgene expression via co-assembly with DNA into fiber core–shelltriplexes. J. Mater. Chem. B 1(45), 6271-6282
Wang Q, Jiang M,Isupov MN, Chen Y, Littlechild JA, Sun L, Wu X, Wang Q, Yang W, Chen L, LiQ, Wu Y. The crystal structure of ArabidopsisBON1 provides insights into the copine protein family. Plant J. 2020 Aug;103(3):1215-1232. doi: 10.1111/tpj.14797.Epub 2020 Jun 13.PMID: 32369638
Wang Q, Chen Y, LiS, Yang W, Sun L, Jang M, Wu X, Wang Q, Chen L, Wu Y. Ca2+-based allosteric switches andshape shifting in RGLG1 VWA domain. Comput Struct Biotechnol J. 2020 Mar 30;18:821-833. doi:10.1016/j.csbj.2020.03.023.
Sun L, Miao Y, Wang Z, Chen H, Dong P, Zhang H, Wu L, Jiang M, Chen L,Yang W, Lin P, Jing D, Luo Z, Zhang Y, Jung YS, Wu X, Qian Y, Wu Y. Structural insight into African swine fever virus I73R protein reveals it as a Z-DNAbinding protein. Transbound Emerg Dis. 2022 Mar21. doi: 10.1111/tbed.14527.
Lifei Chen, Leiqing Chen, Huan Chen, Hong Zhang, PanPan Dong, LifangSun, Xiaojing Huang, Pingdong Lin, Linjiao Wu, Dingding Jing, Yingjuan Qian, Yunkun Wu. Structural insights into theCP312R protein of the African swine fever virus. Biochem Biophys Res Commun,2022, 624:68-74. DOI:10.1016/j.bbrc.2022.07.091
Wu X, Zhao Y, SunL, Jiang M, Wang Q, Wang Q, Yang W, WuY. Crystalstructure of CagV, the Helicobacter pylori homologue of the T4SS protein VirB8.FEBS J. 2019 Nov;286(21):4294-4309. doi: 10.1111/febs.14971.
Zhao Y, Ye X, Su Y, Sun L,She F, Wu Y. Crystal structureconfirmation of JHP933 as a nucleotidyltransferase superfamily protein fromHelicobacter pylori strain J99. PLoS One 2014 Aug 7;9(8):e104609.doi: 10.1371/journal.pone.0104609.
Jiang M, Sun L,Isupov MN, Littlechild JA, Wu X, Wang Q, Wang Q, Yang W, Wu Y. Structuralbasis for the Target DNA recognition and binding by the MYB domain of phosphatestarvation response 1. FEBS J. 2019 Jul;286(14):2809-2821.doi: 10.1111/febs.14846.
Lifang Sun, YintaoSu, Yanhe Zhao, Zheng-qing Fu, Yunkun Wu.Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus.Scientific Reports.2016 Aug 30;6:32309. doi: 10.1038/srep32309.
Sun L, Zou X,Jiang M, Wu X, Chen Y, Wang Q, Wang Q, Chen L, Wu Y*. The crystal structure of the TCPdomain of PCF6 in Oryza sativa L. reveals an RHH-like fold. FEBS Lett. 2020 Jan 3. doi: 10.1002/1873-3468.13727
Facile synthesis of Silicon quantumdot-Gadolinium: A potential fluorescent/T1-T2 multimodal imaging agent.Xiao F, Xiao Y, Chen F, Liu X, Lin C, Chen J, Wu Y. Talanta. 2019 Jul 1;199:336-346. doi:10.1016/j.talanta.2019.02.041.
Weibin Zhang#,Chunhua Zhu#, Fangnan Xiao, Xiaodong Liu, Anhua Xie, Fangman Chen, Panpan Dong,Pingdong Lin, Chenyang Zheng, Hong Zhang, Hui Gong*, Yunkun Wu*. pH-controlledrelease of antigens using mesoporous silica nanoparticles delivery system fordeveloping a fish oral vaccine. Front Immunol, 2021,12 (1173), 1-13. doi: 10.1016/j.mcp.2021.101708.
研究组热忱邀请感兴趣的学生报考硕士、博士研究生！！！
研究组具备充足的科研经费及一流的科研环境和实验设备，诚聘教授/副教授/讲师/研究助理，欢迎有志于科研的青年才俊加盟团队。同时欢迎热爱科研工作的本科生参与科研课题。