承担的主要科研课题:
1.BMP/Wnt信号内稳态破坏导致小鼠肺气肿的机制(项目负责人),项目来源:国家自然科学基金(81570036),2016.1-2017.12
2.心脏起搏细胞的体外诱导及其功能验证(项目负责人),项目来源:福建省科技厅重点项目(2015I0011),2015.6-2018.6
3.Ang2-siRNA质料壳聚糖磁性纳米微粒靶向作用恶性黑色素瘤的实验研究(项目负责人),项目来源:卫生攻关项目(WKJ-FJ-03),2013.11-2016.11
4.牙齿早期发育中BMP信号稳态的调制机制(项目负责人),项目来源:国家自然科学青年基金(81100730),2012.1-2014.12
5.BMP信号在牙齿发育中的作用机制(项目负责人),项目来源:福建省自然科学基金(2012J01119),2012.1-2014.12
6.人类牙齿发育的分子调控机制(项目负责人),项目来源:福建省自然科学基金(2011J01143),2010.7-2011.9
7.牙齿早期发育过程中noggin对BMP信号的调制机制(项目负责人),项目来源:福建省教育厅,2012.1-2014.12
8.可调控的满病毒载体的构建及其作用效率的检测(项目负责人),项目来源:福建省教育厅,2006.1-2008.12
9.提高诱导人表皮干细胞牙向分化的效率及其机制(第二负责人),项目来源:博士点基金项目,2013.1-2015.12
代表作:
1.Huang F, Hu X, Fang C, Liu H, Lin X, Zhang Y,Hu X*.. Expression profile of critical genes involved in FGF signaling pathway in the developing human primary dentition. 144:457-469, 2015.
2.Dong X, Shen B, Ruan L, Guan Z, Zhang Y, Chen Y,Hu X*.Expression patterns of genes critical for BMP signaling pathway in human tooth germs. Histochem Cell Biol.142(6):657-65. doi: 10.1007/s00418-014-1241-y,2014.
3.Huang Z﹟,Hu X﹟, Lin C, Li H, Huang Y, Chen Y, Zhang Y. Genome-Wide Analysis of Gene Expression in the Cap Stage of the Human Embryonic Tooth Germ..J Mol His.45:609-617DIO:10.1007/s10735-014-9580-5), 2014.
4.He F﹟,Hu X﹟, Xiong W, Li L, Lind L, Shen B, Yang L, Gu S, Zhang Y, Chen Y. Directed Bmp4 expression in neural crest cells generates a genetic model for the rare human bony syngnathia birth defect. Dev Biol 391:170-181, 2014.
5.Hu X, Lin C, Shen B, Ruan N, Guan Z, Chen Y, Zhang Y. 2014.Conserved odontogenic potential in embryonic dental tissue.J Dental Res .93:490-495,2014
6.Hu X,Xu S,Lin C,Zhang L,Chen Y,Zhang Y. Precise chronology of differentiation of developing human primary dentition. Histochem Cell Biol .141:221-227,2014.
7.Hu X, Zhang S, Chen G, Lin C, Chen Y, Zhang Y. Expression of SHH Signaling Molecules in the Developing Human Primary Dentition. BMC Dev Biol 13:11.2013.
8.Hu X, Wang Y, He F, Li L, Zheng Y, Zhang Y and Chen YP. Noggin Is Required for Early Development of Murine Upper Incisors. J Dent Res 91(4):394-400.2012.
9.Liu H, Espinoza-Lewis RA, Chen C, Hu X, Zhang Y, Chen YP. The role of Shox2 in SAN development and function. Pediatr Cardiol (DOI 10.1007/s00246-012-0179-x),2012.
10.Zheng L, Yang F, Shen H,Hu X, Mochizuki C, Sato M, Wang S, Zhang Y.The effect of composition of calcium phosphate composite scaffolds on the formation of tooth tissue from human dental pulp stem cells.Biomaterials 32(29):7053-9,2011.
11.Liu H, Chen CH, Espinoza-Lewis RA, Jiao Z, Sheu I,Hu X, Lin M, Zhang Y, Chen Y.Functional redundancy between human SHOX and mouse Shox2 genes in the regulation of sinoatrial node formation and pacemaking function.J Biol Chem13;286(19):17029-38,2011.
12.王冰梅,刘英,林程琳,张彦定,胡雪峰*,CHIR-99021与FGF8协同诱导人表皮干细胞牙向分化,中国生物化学与分子生物学报,2014,30(8)778-786。
13.胡雪峰 许姗 林鑫 等 体外培养的人牙胚上皮细胞的成釉分化,中国生物化学与分子生物学报,2014,30(1)44-51。