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陈骐 教授

时间：2014-08-26浏览：29518


陈骐


  1. 个人简介

陈骐博士是福建省天然免疫生物学重点实验室主任，福建师范大学生命科学学院副院长、南方生物医学研究中心副主任、特聘教授、博士生导师，2016届福建师范大学学术委员会委员，2012年入选福建省高校领军人才。目前主要从事疾病的免疫调控、CRISPR基因编辑、免疫细胞与基因治疗的研究。

是我国最早从事基因工程研究的一批研究生之一，于1985年获福建师范大学学士学位，1988年中国农业科学院硕士学位，1992年及1999年分别获得中国农业科学院及美国南加利福尼亚大学博士学位；1989-1992年在美国罗格斯大学做访问学者；1999-2009年美国索克生物学研究所博士后及副研究员；2010-2012年美国西弗吉尼亚大学洛克菲勒神经生物学研究所助教授。早年主要从事植物基因工程及分子生物学研究工作，1994年后主要从事神经系统功能及相关疾病的研究，在世界上首次分离和克隆了一种新的小G蛋白鸟苷酸交换因子，并完成该基因剔除小鼠模型的构建。

承担过多项国家自然科学基金项目、教育卫生联合攻关项目、福建省自然基金重点项目等。已发表SCI论文130余篇，被引6000余次，其中包括Nature Immunology、 Proceedings of the National Academy of Sciences、Molecular Therapy、Journal of Cell Biology、Journal of Neuroscience等国际高端期刊的文章；获授权发明专利6篇。已培养硕士研究生90余人、博士研究生30人。

是科技部重点研发项目及重大科技专项评审专家，同时兼任福建省药理学会副理事长、福建省免疫学会常务理事、福建省肿瘤生物治疗重点实验室学术委员会委员、福建省药理学重点实验室学术委员会委员、福建省海峡肿瘤防治科技交流协会肿瘤临床研究协作分会顾问及中国侨商会科技创新委员会委员、福建省新侨人才联谊会常务理事等学术及社会职务。

  1. 研究方向和领域

  • 基于cGAS/STING靶点的免疫调节机制研究及药物研发

  • 免疫细胞治疗、CRISPR基因编辑技术及基因治疗

  • 基因分子诊断与精准医学。

  1. 主要科研项目

  • 2023年1月-2026年12月: 国家自然科学基金区域创新发展联合基金，NFE2L2-cGAS-STING信号通路在中国人食管鳞癌放疗和免疫治疗中的作用机制研究。

  • 2024年1月-2026年12月: 国家自然科学基金委员会原创探索计划项目（指南引导类），HSV-1溶瘤病毒原位标记肿瘤并诱导产生通用型CAR-T细胞。

四、主要获奖成果

    • 入选2024年全球前2%顶尖科学家榜单。

    • 第五届中国“互联网+”大学生创新创业大赛金奖项目导师。

  1. 代表性论著

  1. Shen Y, Zhang H, Xue M, Zheng C, Chen Q*. HSV-1 as a gene delivery platform for cancer gene therapy. Trends Pharmacol Sci. 2025 Apr;46(4):324-336. doi: 10.1016/j.tips.2025.02.006.

  2. Chiang ZC, Xu S, Zhao X, Liu M, Lin J, Chen Q*. Generation and characterization of 7DC-DM1: a non-cleavable CD47-targeting antibody-drug conjugates with antitumor effects. Int J Biol Macromol. 2025 May;310(Pt 1):142844. doi: 10.1016/j.ijbiomac.2025.142844.

  3. Xu S, Xiao N, Du H, Zhou X, Huang M, Feng S, Hu S, Zhang X, Zhang S, Cui D, Zhang S, Chen Q*. The SLE-associated TREX1-P212fs mutation disrupts ER association leading to type I interferonopathy. FASEB J. 2024 Dec 15;38(23):e70213. doi: 10.1096/fj.202401579R.

  4. Liu Z, Guo D, Wang D, Zhou J, Chen Q*, Lai J. Prime editing: A gene precision editing tool from inception to present. FASEB J. 2024; 38:e70148. doi:10.1096/fj.202401692R.

  5. Cui D, Zhang Y, Zheng B, Chen L, Wei J, Lin D, Huang M, Du H, Chen Q*. Pim1 is critical in T-cell-independent B-cell response and MAPK activation in B cells. J Mol Biol. 2024 Nov 4:168824. doi: 10.1016/j.jmb.2024.168824.

  6. Zhang Y, Zhao H, Deng W, Lai J, Sang K, Chen Q*. Zebularine potentiates anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through cGAS-STING pathway. Commun Biol. 2024 May 16;7(1):587. doi: 10.1038/s42003-024-06271-w. PMID: 38755254; PMCID: PMC11099016.

  7. Li G, Zhao X, Zheng Z, Zhang H, Wu Y, Shen Y, Chen Q*. cGAS-STING pathway mediates activation of dendritic cell sensing of immunogenic tumors. Cell Mol Life Sci. 2024 Mar 21;81(1):149. doi: 10.1007/s00018-024-05191-6.

  8. Chen J, Wen Y, Lin L, Cui Y, Chen Z, Gao J, Zhuang Y, Chen Q*. Fosl2 Deficiency Predisposes Mice to Osteopetrosis, Leading to Bone Marrow Failure. J Immunol. 2024 Apr 1;212(7):1081-1093. doi: 10.4049/jimmunol.2300592. PMID: 38380993.

  9. Cui D, Zhang Y, Chen L, Du H, Zheng B, Huang M, Li X, Wei J, Chen Q*. CD30 plays a role in T-dependent immune response and T cell proliferation. FASEB J. 2024 Jan;38(1):e23365. doi: 10.1096/fj.202301747RR.

  10. Zhao Y, Gan L, Ke D, Chen Q*, Fu Y. Mechanisms and research advances in mRNA antibody drug-mediated passive immunotherapy. J Transl Med. 2023 Oct 4;21(1):693. doi: 10.1186/s12967-023-04553-1.

  11. Lai J, Liang J, Zhang Y, Zhang B, Wei J, Fan J, Chen L, Chen Z, Li Q, Guo D, Lin J, Chen Q*. A drug-delivery depot for epigenetic modulation and enhanced cancer immunotherapy. Biomed Pharmacother. 2023 Dec;168:115687. doi: 10.1016/j.biopha.2023.115687.

  12. Du H, Kou M, Deng W, Zhou X, Zhang X, Huang Z, Ren B, Cai X, Xu S, Chen Y, Chen L, Chen C, Bao H, Chen Q*, Li D. DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1-/- mice. Biomed Pharmacother. 2023 Sep;165:115188. doi: 10.1016/j.biopha.2023.115188.

  13. Du H, Xiao N, Zhang S, Zhou X, Zhang Y, Lu Z, Fu Y, Huang M, Xu S, Chen Q*. Suppression of TREX1 deficiency-induced cellular senescence and interferonopathies by inhibition of DNA damage response. iScience. 2023 Jun 10;26(7):107090. doi: 10.1016/j.isci.2023.107090.

  14. Zhang Y, Cui D, Huang M, Zheng Y, Zheng B, Chen L, Chen Q*. NONO regulates B-cell development and B-cell receptor signaling. FASEB J. 2023 Apr;37(4):e22862. doi: 10.1096/fj.202201909RR.

  15. Zheng J, Zhou X, Fu Y, Chen Q*. Advances in the Study of Hyperprogression of Different Tumors Treated with PD-1/PD-L1 Antibody and the Mechanisms of Its Occurrence. Cancers(Basel). 2023 Feb 18;15(4):1314. doi: 10.3390/cancers15041314.

  16. Gan L, Zhao Y, Fu Y,Chen Q*. The potential role of m6A modifications on immune cells and immunotherapy. Biomed Pharmacother. 2023 Apr;160:114343. doi: 10.1016/j.biopha.2023.114343.

  17. Chiang ZC, Fang S, Shen YK, Cui D, Weng H, Wang D, Zhao Y, Lin J, Chen Q*. Development of Novel CD47-Specific ADCs Possessing High Potency Against Non-Small Cell Lung Cancer in vitro and in vivo. Front Oncol. 2022 May 12;12:857927. doi: 10.3389/fonc.2022.857927. PMID: 35646646; PMCID: PMC9133542.

  18. Su M, Zheng J, Gan L, Zhao Y, Fu Y, Chen Q*. Second Messenger 2'3'-cyclic GMP-AMP (2'3'-cGAMP): Synthesis, transmission, and degradation. Biochem Pharmacol. 2022 Jan 29:114934. doi: 10.1016/j.bcp.2022.114934.

  19. Lai J, Fu Y, Tian S, Huang S, Luo X, Lin L, Zhang X, Wang H, Lin Z, Zhao H, Lin S, Zhao J, Xu S, Li D, Cai S, Dong L, Qian J, Liang J, Li Q, Zhang Y, Fan J, Balderas R, Chen Q*. Zebularine elevates STING expression and enhances cGAMP cancer immunotherapy in mice. Mol Ther. 2021 May 5;29(5):1758-1771. doi: 10.1016/j.ymthe.2021.02.005.

  20. Liu L, Zhang Y, Liu T, Ke C, Huang J, Fu Y, Lin Z, Chen F, Wu X, Chen Q*. Pyrroloquinoline quinone protects against exercise-induced fatigue and oxidative damage via improving mitochondrial function in mice. FASEB J. 2021 Apr;35(4):e21394. doi: 10.1096/fj.202001977RR.

  21. Liu Y, Xiao N, Du H, Kou M, Lin L, Huang M, Zhang S, Xu S, Li D, Chen Q*. Celastrol ameliorates autoimmune disorders in Trex1-deficient mice. Biochem Pharmacol. 2020 Aug;178:114090. doi: 10.1016/j.bcp.2020.114090.

  22. Fu Y, Fang Y, Lin Z, Yang L, Zheng L, Hu H, Yu T, Huang B, Chen S, Wang H, Xu S, Bao W, Chen Q*, Sun L. Inhibition of cGAS-Mediated Interferon Response Facilitates Transgene Expression. iScience. 2020 Apr 24;23(4):101026. doi: 10.1016/j.isci.2020.101026.

  23. Lai J, Luo X, Tian S, Zhang X, Huang S, Wang H, Li Q, Cai S, Chen Q*. Compound C Reducing Interferon Expression by Inhibiting cGAMP Accumulation. Front Pharmacol. 2020 Feb 28;11:88. doi: 10.3389/fphar.2020.00088.

  24. Xiao N, Wei J, Xu S, Du H, Huang M, Zhang S, Ye W, Sun L, Chen Q*. cGAS activation causes lupus-like autoimmune disorders in a TREX1 mutant mouse model. J Autoimmun. 2019 Jun;100:84-94. doi: 10.1016/j.jaut.2019.03.001.

  25. Luo Q, Fan Y, Lin L, Wei J, Li Z, Li Y, Nakae S, Lin W, Chen Q*. Interleukin-33 Protects Ischemic Brain Injury by Regulating Specific Microglial Activities. Neuroscience. 2018 Aug 10;385:75-89. doi: 10.1016/j.neuroscience.2018.05.047.

  26. Fan Y, Luo Q, Wei J, Lin R, Lin L, Li Y, Chen Z, Lin W, Chen Q*. Mechanism of salvianolic acid B neuroprotection against ischemia/reperfusion induced cerebral injury. Brain Res. 2018 Jan 15;1679:125-133. doi: 10.1016/j.brainres.2017.11.027.  

  27. Lai J, Wang H, Luo Q, Huang S, Lin S, Zheng Y, Chen Q*. The relationship between DNA methylation and Reprimo gene expression in gastric cancer cells. Oncotarget. 2017 Sep 28;8(65):108610-108623. doi: 10.18632/oncotarget.21296.

  28. Liu L, Wu X, Zhang B, Yang W, Li D, Dong Y, Yin Y, Chen Q*. Protective effects of tea polyphenols on exhaustive exercise-induced fatigue, inflammation and tissue damage. Food Nutr Res. 2017 Jun 1;61(1):1333390. doi: 10.1080/16546628.2017.1333390.

  29. Wang H, Ke H, Zheng Y, Lai J, Luo Q, Chen Q*. A modified bisulfite conversion method for the detection of DNA methylation. Epigenomics. 2017 Jul;9(7):955-969. doi: 10.2217/epi-2016-0174.

  30. Chen Q, Sun L, Chen ZJ. Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing. Nat Immunol. 2016 Sep 20;17(10):1142-9. doi: 10.1038/ni.3558.

六、联系方式

电子邮箱：chenqi@fjnu.edu.cn

电话：(0591)-22868190