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黄镇副教授

时间:2014-08-25浏览:7451


黄镇

福建师范大学,生命科学学院,副教授

出生年份:1987

手机:15960038226 邮箱:zhuang@fjnu.edu.cn

科学研究方向:

进化与发育生物学

应用生物信息学手段解析物种的基因组演化,性状的分子遗传机理以及颅面部发育的分子机制。

产业化研究方向:

福建省特色经济物种金鱼和棘胸蛙的分子育种、红曲黄酒酿造工艺。

教育经历:

 2011/09-2014/07,福建师范大学,生命科学学院,博士

 2008/09-2011/07,福建师范大学,生命科学学院,硕士

 2004/09-2008/07,福建师范大学,生命科学学院,学士

工作经历:

 2014/09-至今,福建师范大学,生命科学学院,讲师

 2014/10-2016/01,美国杜兰大学,细胞与分子生物学系,访问学者

主持或参加科研项目及人才计划项目情况:

  1. 国家自然科学基金面上项目,82170918,第一腮弓的神经嵴细胞谱系精准追踪及其定向分化的分子机制,55万元,在研(2022/01-2025/12),主持。

  2. 国家自然科学基金青年基金,81700933Shox2调控上腭间充质细胞成骨分化的分子机制,20万元,结题(2018/01-2020/12),主持。

  3. 福建省科技厅引导性项目,2022N0012,金鱼基因组辅助育种技术研发和应用示范,15万元,在研(2022/01-2025/12)

  4. 福建省自然科学基金青年创新项目,2015J05063,Wnt5a对小鼠上腭板发   育的调控机制,3万元,结题(2015/01-2018/3),主持。

  5. 福建省区域专项重大计划,2016N3015,红曲黄酒现代发酵工程技术创新研究及应用,16万元,结题(2016/04-2018/12),主持。

  6. 福建省经信委重点科技项目,干型饮用红曲黄酒技术的研发,9万元,结题(2015/12-2018/12),主持。

  7. 国家自然科学基金面上项目,81271102FGF8介导的信号通路对哺乳动物牙齿发育速率的调控作用,结题,70万元,2013/01-2017/12,参加。

  8. 福建省卫生教育联合攻关项目,WKJ-FJ-24,“病态窦房结综合征细胞与基因治疗技术的研究”,30万元,结题,参加。

发表文章(通讯和第一作者文章)

  1. Zhen Huang(第一作者), Ivanete De O. Furo, Jing Liu, Valentina Peona, Anderson J. B. Gomes, Wan Cen, Hao Huang, Yanding Zhang, Duo Chen, Ting Xue, Qiujin Zhang, Zhicao Yue, Quanxi Wang, Lingyu Yu, Youling Chen*, Alexander Suh, Edivaldo H. C. de Oliveira , Luohao Xu*.Recurrent chromosome reshuffling and the evolution of neo-sex chromosomes in parrots. Nature communications, 2022,13, no.944

  2. Zhen Huang(第一作者), Luohao Xu, The monk parakeet (Myiopsitta monachus), Trends in Genetics, 2022.38(9),985-986.

  3. Ma, Pengcheng#, Xingyan Liu#, Huimin Liu#, Zaoxu Xu#, Xiangning Ding#, Zhen Huang#(共同第一作者), Chenggang Shi, Langchao Liang,, Luohao Xu, Xiaolu Li, Guimei Li, Yuqi He, Zhaoli Ding, Chaochao Chai, Haoyu Wang, Jiaying Qiu,, Jiacheng Zhu,, Xiaoling Wang, Peiwen Ding, Si Zhou, Yuting Yuan, Wendi Wu, Cen Wan, Yanan Yan, Yitao Zhou, Qi-Jun Zhou, Guo-Dong Wang, Qiujin Zhang,* Xun Xu,* Guang Li,* Shihua Zhang,* Bingyu Mao*, Dongsheng Chen*. Joint profiling of gene expression and chromatin accessibility of amphioxus development at single cell resolution. Cell reports , 2022,39(12).

  4. Jue Xu, Meiling Chen, Yanan Yan, Qiaoxue Zhao, Meiying Shao*, and Zhen Huang*共同通讯作者).The effects of altered BMP4 signaling in first branchial-arch-derived murine embryonic orofacial tissues. International Journal of Oral Science 13, no. 1 (2021): 1-8.

  5. Qian Zhang# , Zhen Huang# (共同第一作者), Huanyan Zuo, Yuxiu Lin, Xiao Yao, Yanan Yan, Cui Yu et al. "Chromatin accessibility predetermines odontoblast terminal differentiation." Frontiers in Cell and Developmental Biology: 3271.

  6. Lingzhan Xue, Yu Gao, Meiying Wu, Tian Tian, Haiping Fan, Yongji Huang, Zhen Huang#(共同通讯作者), Dapeng Li#, Luohao Xu#. Telomere-to-telomere assembly of a fish Y chromosome reveals the origin of a young sex chromosome pair, Genome Biology, 2021,22(203).

  7. Duo Chen#, Qing Zhang#, Weiqi Tang#Zhen Huang#,*(共同第一作者,共同通讯作者), Gang Wang#, Yongjun Wang, Jiaxian Shi, Huimin Xu, Lianyu Lin, Zhen Li, Wenchao Chi, Likun Huang, Jing Xia, Xingtan Zhang, Lin Guo, Yuanyuan Wang, Panpan Ma, Juan Tang, Gang Zhou, Min Liu, Fuyan Liu, Xiuting Hua, Baiyu Wang, Qiaochu Shen, Qing Jiang, Jingxian Lin, Xuequn Chen, Hongbo Wang, Meijie Dou, Lei Liu, Haoran Pan, Yiying Qi, Bin Wu, Jingping Fang, Yitao Zhou, Wan Cen, Wenjin He, Qiujin Zhang, Ting Xue, Gang Lin, Wenchun Zhang, Zhongjian Liu, Liming Qu, Aiming Wang, Qichang Ye, Jianming Chen, Yanding Zhang, Ray Ming, Marc Van Montagu*, Haibao Tang*, Yves Van de Peer*, Youqiang Chen*, Jisen Zhang*.The evolutionary origin and domestication history of goldfish (Carassius auratus).Proceedings of the National Academy of Sciences.2020, 117(47):29775-29785

  8. Yitao Zhou, Shijun Xiao, Gang Lin, Duo Chen, Wan Cen, Ting Xue, Zhiyu Liu, Jianxing Zhong, Yanting Chen, Yijun Xiao, Jianhua Chen, Yunhai Guo, Youqiang Chen, Yanding Zhan1, Xuefeng Hu*, Zhen Huang*(共同通讯作者). Chromosome genome assembly and annotation of the yellowbelly pufferfish with PacBio and Hi-C sequencing data. 2019, Scientific data, 6(1):1-8.

  9. Jue Xu, Linyan Wang, Hua Li, Tianfang Yang, Yanding Zhang, Tao Hu* , Zhen Huang* (共同通讯作者),YiPing Chen*. Shox2 regulates osteogenic differentiation and pattern formation during palatogenesis.Journal of Biological Chemistry.2019, 294(48):18294-18305

  10. Jue Xu#, Zhen Huang#(共同第一作者), Weiqi Wang, Xiaoqian Tan, Hua Li, Yanding Zhang, Tao Hu, YiPing Chen. FGF8 Signaling Alters the Osteogenic Cell Fate in the Hard Palate. Journal of dental research, 2018,1.

  11. Zhen Huang #(共同第一作者), Xuefeng Hu #, Chengsheng Lin, Suzhu Chen, Feng Huang , Yanding Zhang*. Genome-Wide Analysis of Gene Expression in Human Embryonic Tooth Germ, Journal of Molecular Histology, 2014, 45(6): 609-617.

    发表文章(署名文章)


  12. Libin He #, Xin Long#, Jianfei Qi#, Zongji Wang#, Zhen Huang, Shuiqing Wu, Xingtan Zhang et al. "Genome and gene evolution of seahorse species revealed by the chromosome‐level genome of Hippocampus abdominalis." Molecular ecology resources (2021).

  13. Wu, Benyang, Xiaoyan Chai, Aiming He, Zhen Huang, Sheng Chen, Pingfan Rao, Lijing Ke, and Leiwen Xiang. "Inhibition of acrylamide toxicity in vivo by Arginine-Glucose Maillard reaction products." Food and Chemical Toxicology (2021): 112315.

  14. Feng, Huimin, Kun Qiao, Chunchun Wang, Bei Chen, Min Xu, Hua Hao, Zhen Huang, Zhiyu Liu, and Qin Wang. "Multi-Omics Analysis of Gene and Protein Candidates Possibly Related to Tetrodotoxin Accumulation in the Skin of Takifugu flavidus." Marine Drugs 19, no. 11 (2021): 639.

  15. Jixing Zhong, Gen Tang, Jiacheng Zhu, Weiying Wu, Ge Li, Xiumei Lin, Langchao Liang, Chaochao Chai, Yuying Zeng, Feiyue Wang, Lihua Luo, Jiankang Li, Fang Chen, Zhen Huang, Xiuqing Zhang, Yu zhang, Hongde Liu, Xin Qiu, Dongsheng Chen. "Single cell brain atlas of Parkinson’s disease mouse model."2021, Journal of Genetics and Genomics .

  16. Jue Xu, Linyan Wang, Zhen Huang, YiPing Chen, Meiying Shao . Exogenous FGF8 signaling in osteocytes leads to mandibular hypoplasia in mice. 2020, Oral Diseases.00:1-7.

  17. Changwei Bi, Na Lu, Zhen Huang, Junyuan Chen, Chunpeng He, Zuhong Lu. Whole‐genome resequencing reveals the pleistocene temporal dynamics of Branchiostoma belcheri and Branchiostoma floridae populations. 2020, Ecology and Evolution.10(15), 8210-8224.

  18. Hua Li, Dainan Li, Yuzhi Wang, Zhen Huang, Jue Xu, Tianfang Yang, Linyan Wang, Qinghuang Tang, Chen-Leng Cai, Hai Huang, Yanding Zhang, YiPing Chen. Nkx2-5 defines a subpopulation of pacemaker cells and is essential for the physiological function of the sinoatrial node in mice. 2019, Development, 146(14).

  19. Kui Ding , Libin Zhang, Lina Sun, Chenggang Lin, Qiming Feng, Shuangyan Zhang, Hongsheng Yang, Richard Brinkman, Gang Lin, Zhen Huang. Transcriptome analysis provides insights into the molecular mechanisms responsible for evisceration behavior in the sea cucumber Apostichopus japonicus. 2019, Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, 30,143-157.

  20. Wenduo Ye, Yingnan Song, Zhen Huang, Osterwalder M, Ljubojevic A, Xu J, Bobick B, Abassah-Oppong S, Ruan N, Shamby R, Yu D, Zhang L, Cai C, Visel A, Yanding Zhang, Cobb J, Yiping Chen. A unique stylopod patterning mechanism by Shox2-controlled osteogenesis. Development, 2016, 143(14): 2548-2560.

  21. Wenduo Ye, Yingnan Song, Zhen Huang, Yanding Zhang, Yiping Chen, Genetic Regulation of Sinoatrial Node Development and Pacemaker Program in the Venous Pole, Journal of cardiovascular development and disease, 2015, 2(4), 282-298

  22. Yide Huang, Ruonan Zhen, Meiqin Jiang, Jie Yang, Yun Yang, Zhen Huang, Yao Lin. Development of all‐in‐one multicistronic Tet‐On lentiviral vectors for inducible co‐expression of two transgenes.2015, Biotechnology and applied biochemistry, 62.1: 48-54.

  23. Qianqian Lin, Mei Yang, Zhen Huang, Wei Ni, Guo liang, Guowei Guo, Zhengchao Wang, Xiaohong Huang, Cloning, expression and molecular characterization of a 14-3-3 gene from a parasitic ciliate, Cryptocaryon irritans, Veterinary parasitology , 2013, 197(3): 427-435

  24. Xuefeng Hu, Shuo Zhang, Guimiao Chen, Chengsheng Lin, Zhen Huang, Yiping Chen, Yanding Zhang, Expression of SHH signaling molecules in the developing human primary dentition, BMC developmental biology , 2013, 13(1): 1-8

    获奖情况

  1. 福建红曲醋酿造新工艺研究。福建省科技进步奖, 三等奖, 2014-01-25,黄祖新、陈由强、黄镇、林育民、张晓强。

  2. 有机黄酒研制及产业化。中国食品工业协会科学技术奖,二等奖,2011-08-25,排名第五。

  3. 清爽型红曲黄酒系列产品开发鱼工艺技术集成创新,中国食品科学技术学会科技创新奖-技术进步奖,2014111日,黄祖新、黄镇、王锐军、邱允滔、张文森、陈由强、蒋咏梅、张守财、陈强平、韦信象。

获得专利

  1. 一种金鱼卵低温保存的方法,黄镇,黄祖新,20176月授权,专利编号:ZL201510414888.8

  2. 一种红曲醋豆的制备方法,黄镇,黄祖新,20176月授权,专利编号:ZL201510027557.9

  3. 一种文昌鱼人工催产鱼卵的方法,黄祖新,黄镇,201907月授权,专利编号:ZL 201710427581.0

  4. 一种珊瑚人工养殖缓释颗粒饵料的制备及投喂方法,黄镇,陈多 ,黄祖新,张彦定,陈由强;20201117日授权,专利号:CN201611144870.1

  5. 一种珊瑚分割繁殖的人工培育方法,黄镇,陈多 ,黄祖新,张彦定,陈由强;2019723日授权,专利号:CN201611157717.2

  6. 一种基于人工肌腱支架材料的组织工程化人工肌腱移植物的制备方法,黄镇,黄祖新,周文浩,2019621日,专利号:CN201610534817.6

  7. 一种细菌纤维素膜组织工程化人工肌腱支架的制备方法,黄镇,黄祖新,周文浩,2019910日,专利号:CN201610534635.9

  8. 一种高温大曲浸提液宏蛋白提取纯化方法,黄镇,黄祖新,刘龙山,2019927日,专利号:CN201610721039.1

媒体报道:

  1. 福建日报,2021.10.22, 01头版,《来了科特派 金鱼游得欢》https://fjrb.fjdaily.com/pc/con/202110/22/content_123427.html

  2. 福建日报,2021.08.11, 01头版,《引智入村,乡村蜕变》https://fjrb.fjdaily.com/pc/con/202108/11/content_101321.html

  3. 福州日报,2021.05.0901头版,《在小金鱼上做出大文章,科特派黄镇通过改变遗传密码,助闽侯金鱼声名远播》http://mag.fznews.com.cn/fzrb/2021/20210509/20210509_001/20210509_001_2.htm

  4. 福州日报,2021.02.0201头版《闽侯积极引进院士专家驻点设站 推进产学研用一体化》https://mag.fznews.com.cn/h5/fzrb/mobile/2021/20210202/20210202_m.html#page0

  5. 福州晚报,2021.10.06A02 版,《科特派开方小金鱼游出大产业》https://mag.fznews.com.cn/fzwb/2021/20211006/20211006_A02/20211006_A02.html

  6. 福建日报,2020.11.11A03版,《福州金鱼:逍遥数百年,游进好时代》

  7.  https://fjrb.fjdaily.com/pc/col/202011/11/node_03.html

  8. 福建日报,2020.08.2112版,《福建特色蛙类品种棘胸蛙基因组破译》http://fjrb.fjsen.com/fjrb/html/2020-08/21/content_1276803.htm?div=-1