王德民教授

发布时间: 2014-08-29      访问次数: 2706
王德民
教授
系所生命科学学院
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通讯地址福建福州大学城福建师范大学旗山校区生命科学学院




个人简介:

教授,博士生导师。国家杰出青年基金获得者,美国John B & Judith A Gardetto癌症研究终身讲席教授,国家千人。

教育经历:

1988年南京大学学士、1995年美国田纳西大学博士。

工作经历:

1995-2000美国St Jude 儿童研究医院生化部博士后。

2000-2004 美国威斯康星血液研究所副研究员(助理教授)

2004-2009 美国威斯康星血液研究所研究员(副教授)

2009-2016 美国威斯康星血液研究所高级研究员(教授)

2003-2016南京大学生命科学学院兼职教授

2013-现在美国John B and Judith A Gardetto癌症研究终身讲席教授。

2013国家千人

2016-现在福建师范大学生命科学学院教授

研究方向:

研究免疫系统中淋巴细胞发育和功能的生物学及信号传导的分子调控机理,以及研究造血干细胞的功能和分子调控机理。

国际学术兼职:

2003-2004 美国威斯康星州血液研究所免疫学教职招聘委员会委员

2006-2010 美国威斯康星州医学院研究生学习委员会委员

2011-2012 美国威斯康星州血液研究所免疫学教职招聘委员会共同主席

2014-现在美国威斯康星州血液研究所干细胞学教职招聘委员会主席

2011-2015基金评审正式委员,分子和细胞血液学研究部,美国国家卫生研究院

2012-现在 副主编,Journal of Immunology

国际学术会议:

2005美国芝加哥第三十四届年度秋季免疫学会议,B细胞激活和通路讨论会主席

2007组织中国南京分子免疫学国际研讨会

2008组织中国南京分子免疫学国际研讨会

2009 组织中国丽江第三届国际传染病和免疫研讨会

2012美国芝加哥B41届年度秋季免疫学会议细胞发育研讨会主席

2013美国威斯康星州第7届年度人类免疫学研讨会中心委员会共同主席

2013美国血液学会美国血液学会,淋巴细胞,淋巴细胞活化和免疫缺陷,包括艾滋病毒和其他感染:B细胞和先天免疫细胞研讨会共同主席。

2014美国威斯康星州第8届年度人类免疫学研讨会委员会主席。

获奖:

2003-2007美国癌症学会研究奖

2005-2007中国自然科学基金海外杰出青年基金

2007-2012美国白血病和淋巴瘤学会学者奖

2013-至今国家千人

审稿专家:

Nature Reviews Immunology, Proceedings of the National Academy of Sciences, Blood, Molecular and Cellular Biology, Journal of Biological Chemistry, Journal of Immunology, Oncogene, et al

基金评审专家:

2004Ad hoc reviewer, the National Science Foundation (美国国家科学基金会)

2006Member, ZAI1 PA-I S2, Special Emphasis Panel, NIAID, NIH (美国国家卫生部)

2007 Ad hoc reviewer, Allergy, Immunology, and Transplantation Research Committee (AITRC), NIAID, NIH (美国国家卫生部)

2007Member, ZAI1-SV-I-S1, Special Emphasis Panel, NIAID, NIH (美国国家卫生部)

2009Ad hoc reviewer, Hematopoiesis Study Section, NHLBI, NIH (美国国家卫生部)

2010Member, ZRG1-VH-F 02M, Hematopoietic Cellular Mechanisms Special Emphasis Panel, NHLBI, NIH (美国国家卫生部)

2010Ad hoc reviewer, Molecular and Cellular Hematology Study Section, NIH (美国国家卫生部)

2011Member, American Cancer Society, Leukemia, Immunology and Blood Cell development Study Section (美国肿瘤协会)

2011Member, ZRG1 VH-C, Special Emphasis Panel, NHLBI, NIH (美国国家卫生部)

2011Ad hoc reviewer, the Leukemia Research Foundation (美国国家科学基金会)

2006-2015 Member, Medical College of Wisconsin Cancer Center Grant (美国威斯康星医学院)

2012Member, the New York State Department of Health’s Stem Cell Science Program (纽约州卫生部干细胞科学计划)

2012Ad hoc reviewer, American Society of Hematology (ASH), Atlanta, GA, 2012

2011-2015 Regular member, Molecular & Cellular Hematology Study Section, NIH (美国国家卫生部)

研究论文:

(Publications selected from 78 publications)

  1. Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y and Ihle JN. Erythropoietin induces activation of stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol. Cell. Biol. 16:1622-1631, 1996.

  2. Wang D, Stravopodis D, Teglund S, Kitazawa J, and Ihle JN. Naturally occurring dominant negative variants of stat5. Mol. Cell. Biol. 1996;16:6141-6148.

  3. Quelle FW, Wang J, Feng J, Wang D, Cleveland JM, Ihle JN, and Zembetti GP. Cytokine rescue of p53-dependent apoptosis and cell cycle arrest is mediated by distinct JAK kinase signaling pathways. Genes Dev. 1998;12:1099-1107.

  4. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, and Ihle JN. Stat5 A and B proteins have essential and non-essential, or redundant, roles in cytokine response. Cell 1998;93:841-850.

  5. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colarnonici OR, van Deursen JM, Grosveld G, and Ihle JN. Jak2 is essential for signaling through a variety of cytokine receptors. Cell 1998;93:385-395.

  6. Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, and Ihle JN. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 1999;10:249-259.

  7. Cheng M, Wang D, and Roussel MF. Expression of c-Myc in response to colony-stimulating factor-1 requires mitogen-activated protein kinase kinase-1. J. Biol. Chem. 1999;274:6553-6558.

  8. Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima A, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, and Ihle JN. SOCS-III is essential in the regulation of fetal liver erythropoiesis. Cell 1999;98:617-627.

  9. Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D,Yoshimura A, and Ihle JN. SOCS-1 deficiency causes a lymphocyte dependent perinatal lethality. Cell 1999;98:609-616.

  10. Wang D, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, and Ihle JN. A small amphipathic α-helical region is required for transcriptional activities and proteosome-dependent turnover of the tyrosine phosphorylated Stat5. EMBO J. 2000;19:392-399.

  11. Schwaller J, Parganas E, Wang D, Cain D, Aster JC, Williams IR, Lee CK, Gerthner R, Kitamura T, Frantsve J, Anastasiadou E, ML, Levy DE, Ihle JN, Gilliland GD. Stat5 is essential for the myelo- and lympho-proliferative disease Induced by TEL/JAK2 through regulation of Oncostatin M. Molecular Cell 2000;6:693-704.

  12. Wang D, Feng J, Wen R, Marine JC, Sangster MS, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JM, Murray PJ, and Ihle JN. Phospholipase C2 is essential in the functions of B cell and several Fc Receptors. Immunity, 2000;13:25-35.

  13. Wen R,Wang D, McKay C, Bunting KD, Marine JC, Zembetti GP, Ihle JN, and Cleveland JM. Jak-3 provides a survival signal downstream of IL-7 signaling pathway. Mol. Cell. Biol. 2001;21:678-689.

  14. Wen R, Jou S, Chen Y, Hoffmeyer A and Wang D. Phospholipase C2 is essential for specific functions of FcR and FcR. J. Immunol. 2002;169:6743-6752.

  15. Jou S, Carpino N, Takahashi Y, Piekorz R, Chao J, Carpino N, Wang D and Ihle JN. An essential, non-redundant role for the phosphoinositide 3-kinase p110d in signaling by the B Cell receptor complex. Mol. Cell. Biol. 2002;22:8580-8591.

  16. Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, and Gartner TK. The roles of IIb3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood 2003;101:2646-2651.

  17. Chen Y, Wen R, Yang S, Schuman J, Zhang EE, Yi T, Feng GS and Wang D. Identification of Shp-2 as a Stat5A phosphatase. J. Biol. Chem. 2003;278:16520-16527.

  18. Xue L, Morris SW, Orihuela C, Tuomanen E, Cui X, Wen R and Wang D. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nature Immunology 2003;4:857-865.

  19. Wen R, Chen Y., Xue L, Schuman J, Yang S, Morris SW and Wang D. Phospholipase C2 provides survival signals via Bcl-2 and A1 in different subpopulations of B cells. J. Biol. Chem. 2003;278:43654-43662.

  20. Zhu Y, Chen L, Huang Z, Alkan S, Bunting KD, Wen R, Wang D, and Hua Huang. IL-5 primes Th2 cytokine-producing capacity in eosinophils through a STAT5-dependent mechanism. J. Immunol. 2004;173:2918-2922.

  21. Wen R, Chen Y, Schuman J, Yang S, Newman D and Wang D. An important role of phospholipase Cg1 in pre-B-cell development and allelic exclusion. EMBO J. 2004;23:4007-4017.

  22. Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, Hoffmeyer A, Bauer A, Piekorz R, Wang D, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell 2005;7:87-99.

  23. Regunathan J, Chen Y, Wang D and Malarkannan S. NKG2D-mediated NK cell cytotoxicity is regulated by Inhibitory Ly49 Receptors.Blood2005;105:233-240.

  24. Zhu M, Granillo O, Wen R, Yang K, Dai X, Wang D, and Zhang W. Negative regulation of lymphocyte activation by the adaptor protein LAX. J. Immunol. 2005;174: 5612 – 5619.

  25. Mutsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X. Phosphorylation of CARMA1 plays a critical role in T cell receptor-mediated NF-B activation. Immunity 2005;23:575-585.

  26. Dai X, Chen Y, Schuman J, Hua Z, Adamson JW, Wen R, Wang D. Distinct roles of PI3K and PLC2 in B cell receptor-mediated signal transduction. Mol. Cell. Biol. 2006;26:88-99.

  27. Cheeseman KL, Kashiwagi K, Michaud T, Ueyama T, Wang D, Flax LA, Shirai Y, Loegering DJ, Saito N, and Lennartz MR. Targeting of PKC-ε during FcγR-dependent phagocytosis requires the εC1B domain and phospholipase C-γ1. Mol. Biol. Cell. 2006;17:799-813.

  28. Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, and Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B-cells. Blood 2006; 107:4407-4416.

  29. Chen Y, Dai X, Haas AL, Wen R, Wang D.Proteasome-dependent down-regulation of activated Stat5A in the nucleus. Blood 108:566-574, 2006.

  30. Regunathan J, Chen Y, Kutlesa S, Dai X, Bai L, Wen R, Wang D*, and Malarkannan S*. Differential and non-redundant roles of PLCγ2 and PLCγ1 in the terminalmaturation of NK cells1. J. Immunol. 2006; 177:5365-5376. (*equal senior authorship).

  31. Hoek KL, Antony P, Lowe J, Shinners N, Sarmah B, Wente SR, Wang D, Gerstein RM and Khan WN. Transitional B cell fate is associated with developmental stage-specific regulation of diacylglycerol and calcium signaling upon B cell receptor engagement. J. Immunol. 2006; 177:5405-5413.

  32. Wen R, Chen Y, Fu G, Schuman J, Yang C, Stephan RP,Cleveland JL and Wang D. An essential role of phospholipase Cg2 in early B cell development and Myc-mediated lymphomagenesis. Mol. Cell. Biol. 2006; 26: 9364–9376.

  33. Chen Y, Pappu B, Zeng H, Xue L, Morris SW, Lin X, Wen R and Wang D. Bcl10 is essential for FcR-mediated degranulation and IL-6 production in mast cells. J. Immunol. 2007; 178:49-57.

  34. Blonska M, Pappu BP, Matsumoto R, Li H, Su B, Wang D, and Lin X. The CARMA1-Bcl10 Signaling Complex Selectively Regulates JNK2 Kinase in the T Cell Receptor-Signaling Pathway. Immunity 2007; 26:55-66.

  35. Yang XO, Panopoulos AD, Nurieva R, Chang SH, Wang D, Watowich SS, and Dong C. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells. J. Biol. Chem. 2007; 282:9358-9363.

  36. Zhou M, McPherson L, Feng D, Song A, Dong C, Lyu SC, Zhou L, Shi X, Ahn YT, Wang D, Clayberger C and Krensky AM. KLF13 regulates T lymphocyte survival in vivo. J. Immunol. 2007;178:5496-5504.

  37. Misra RS, Russell JQ, Koenig A, Hinshaw-Makepeace JA, Wen R, Wang D, Huo H, Littman DR, Ferch U, Ruland J, Thome M and Budd RC. Caspase-8 and c-FLIPL associate in lipid rafts with NF-kB adaptors during T cell activation. J. Biol. Chem. 2007; 282:19365-19374.

  38. Dai X,Chen Y,Di L, Podd A, Li G, Bunting KD, Hennighausen L, Wen R and Wang D. Stat5 is essential for early B cell development but not for B cell maturation and function. J. Immunol. 2007; 179:1068-1079.

  39. Bai L, Chen Y, He Y, Dai X, Lin X, Wen R and Wang D. Phospholipase C2 contributes to light chain gene activation and receptor editing. Mol. Cell. Biol. 2007; 27:5957-5967.

  40. Malarkannan S, Regunathan J, Chu H, Chen Y, Zeng H, Kutlesa S, Wen R and Wang D. Activation of Bcl10 is essential for the signaling divergence of NKG2D-mediated cytotoxicity and cytokine generation in NK cells. J. Immunol. 2007; 179:3752-3762.

  41. Shinners NP, Carlesso G, Castro I, Hoek K, Corn R, Woodland R, Scott ML, Wang D and Khan WN. Bruton’s tyrosine kinase mediates NF-B activation and B cell survival by B cellactivating factor of the TNF family. J. Immunol. 2007; 179:3872-3880.

  42. Chen Y, Yu M, Podd A, Wen R, Chrzanowska-Wodnicka M, White GC, and Wang D. A critical role of Rap1b in B cell trafficking and marginal zone B cell development. Blood 2008; 111:4627-4636.

  43. Zeng H, Chen Y, Yu M, Xue L, Gao X, Morris SW,Wang D, and Wen R. TCR-mediated activation of CD4+CD44hi T cells bypasses Bcl10. J. Biol. Chem. 2008; 283:24392-24399.

  44. Chen Y, Wang X, Di L, Fu G, Chen Y, Bai L, Liu J, Feng X, McDonald JM, Michalek S, He Y, Yu M, Fu YX, Wen R, Wu H and Wang D. Phospholipase C2 mediates RANKL-stimulated lymph-node organogenesis and osteoclastogenesis. J. Biol. Chem. 2008; 283:29593-29601.

  45. Schulteis RD, Chu H, Dai X, Chen Y, Edwards B, Haribhai D, Williams CB, Malarkannan S, Hessner MJ, Glisic-Milosavljevic S, Jana S, Kerschen EJ, Ghosh S, Wang D, et al. Impaired survival of peripheral T cells, disrupted NK/NKT cell development, and liverfailure in mice lacking gimap5.Blood 2008; 112:4905-4914.

  46. Ohmori K, Luo Y, Jia Y,Nishida J, Wang Z, Bunting KD, Wang D, and Huang H. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by promoting basophil/mast cell common progenitors to differentiate into basophils in the spleen. J. Immunol. 2009; 182: 2835-2841.

  47. Schuman J, Chen Y, Podd A, Yu M, LiuH, Wen R, Chen ZJ, and Wang D. A critical role of TAK1 in B cell development and activation. Blood 2009; 113: 4566-4574.

  48. Fu G, Chen Y, Yu M, Podd A, Schuman J, He Y, Di L, Yassai M, Haribhai D, North PE, Gorski J, Williams CB, Wang D, and Wen R. Phospholipase Cg1 is essential for T-cell development, activation and tolerance. J. Exp. Med.2010; 207: 309-318.

  49. Mueller H, Stadtmann A, Van Aken H, Wang D, Ley K, and Zarbock A. Tyrosine kinase Btk regulates E-selectin-mediated integrinactivation & neutrophil recruitment by controllingphospholipase C (PLC)g2 and PI3Kgpathways. Blood 2010; 115: 3118-3127.

  50. Wuerzberger-Davis S, Chen Y, Yang DT, Bates P, Ladell NC, Yu M, PoddA, ZengH, WenR, WangD* and MiyamotoS*. Nuclear export of the NF-B inhibitor IkB is required for proper B cell and secondary lymphoid tissue formation. Immunity 34:188-200, 2011. *equal senior authorship

  51. Chen Y, Yu M, Dai X, Zogg M, Wen R, Weiler H, and Wang D.Critical role of Gimap5 in the survival of mouse hematopoietic stem and progenitor cells. J. Exp. Med.208: 923-935, 2011.

  52. Gorjestani S, Yu M, Tang B, Zhang D, Wang D, and Lin X. Phospholipase Cγ2 (PLCγ2) Is Key Component in Dectin-2 Signaling Pathway, Mediating Anti-fungal Innate Immune ResponsesJ. Biol. Chem. 286: 43651-43659, 2011.

  53. NurievaRI, Podd A,Chen Y, Alekseev AM, Yu M, Qi X, Huang H, Wen R, Wang J, Li HS, Watowich SS, Qi H, Dong C, and Wang D. STAT5 protein negatively regulates T follicular helper cell generation and function. J. Biol. Chem. 287:11234-11239, 2012.

  54. Malherbe LP and Wang D. Tyrosine kinases enAbling adaptor molecules for chemokine- induced Rap1 activation in T cells. Science Signal 5:pe33, 2012.

  55. FuG, ChenY, WangD, and Wen R. Important role of phospholipase C2 in T-cell receptor signal transduction and T-cell positive selection. J. Immunol.189:2326-2332, 2012.

  56. Yu M, Chen Y,He Y, Podd A, Fu G,Wright JA, Kleiman E, Khan WN, Wen R, and Wang D. Critical role of B cell lymphoma 10 in BAFF-regulated NF-B activation and survival of anergic B cells. J. Immunol.189:5185-5193, 2012.

  57. Zheng Y, Yu M, Podd A, Yuan L, Newman DK,Wen R, Arepally G, and Wang D. Critical role for mouse marginal zone B cells in PF4/heparin antibody production. Blood 121: 3484-3492, 2013.

  58. Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, et al. The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nature Immunology 14: 732-740, 2013.

  59. Qi X, Hong J, Chaves L, Zhuang Y, Chen Y, Wang D, Chabon J, Graham B, Ohmori K, Li Y, and Huang H. Antagonistic regulation by C/EBP and MITF specifies basophil and mast cell fates. Immunity 39: 97-110; 2013.

  60. Zheng Y, Wang AW,Yu M, Padmanabhan A, Tourdot BE, Newman DK, White GC, Aster AH, Wen R, and Wang D. B cell tolerance regulates production of antibodies causing heparin-induced thrombocytopenia. Blood 123: 931-934; 2014.

  61. Padmanabhan A, Jones CG, Daniel W. Bougie DW, Curtis BR, McFarland JG, Wang D and Aster RH. Heparin-independent binding of HIT antibodies to platelets: Implications for HIT pathogenesis. Blood 125:155-161; 2015.

  62. Yongwei Zheng, Yu M, Padmanabhan A, Aster RH, Yuan L, Wen R, and Wang D. Critical role of T cells in PF4/heparin antibody production. Blood 125:1826-1829; 2015.

  63. Yan X., Yan MF, Guo YH, Singh G, Chen Y, Yu M, Wang D, Hillery CA and Chan AM. R-Ras regulates murine T cell migration and intercellular adhesion molecule-1 binding. PLoS One (In press).

  64. Xin G, Lainez B, Weinstein J, Dai Z, Chen Y, Esplugues E, Wen R, Wang D, Craft J, and Cui W. A critical role of IL-21 induced BATF in sustaining CD8 T cell mediated chronic viral control. Cell Report (In press).

  65. Chen Y, Zheng Y, You X, Yu M, Fu G, Su X, Zhou F, Zhu W, Wu Z, Zhang J, Wen R, and Wang D. Kras is critical for B cell lymphopoiesis. J. Immunol. (In Press).