洪炎国 教授

发布时间: 2014-08-27      访问次数: 2717

人简介:男,湖北武汉人,教授,博士生导师。

社会兼职:中国神经科学学会感觉运动组委员,中国疼痛学会基础学组委员

通讯联系:yhong@fjnu.edu.cn 手机:18950443876

教育经历:博士

工作经历:1982年获湖北医学院 (现武汉大学) 医学硕士学位; 1991获加拿大McGill大学生理学博士学位。在加拿大多所大学作博士后研究,并任职于AstraZeneca 跨国药物公司蒙特利尔药物开发研究所。

研究方向:从事于神经科学方面的研究二十余年, 其领域先后主要有心血管活动的中枢神经调节、老年痴呆症的神经病理机制、痛觉生理和炎症机理与治疗等。

成果与奖励:主持六项国家自然科学基金、一项教育部基金、一项省科技厅重点项目、多项省级基金。

作为主持人获得国家发明专利二项、美国发明专利一项2003年到师大工作至今发表论文60余篇(其中SCI文章32篇)。获福建省自然科学优秀论文一等奖一篇、二等奖二。获得20112013度福建省科学技术奖二等奖(均排名第一)

在研项目:

1. 国家自然科学基金—2014年至2017年,项目号:31371124,主持人

      项目名称:MrgC受体调控慢性吗啡诱发神经胶质细胞激活的研究

2. 教育部博士点基金—2013年至2015年,项目号:20113503110001主持人

   项目名称:应用吗啡对肾上腺髓质素的影响及促成吗啡耐受的生物学机制

3. 国家自然科学基金 —2012年至2015年,项目号:31171072,主持人

项目名称:痛介导质肾上腺髓质素参与炎性痛和吗啡耐受的神经生物学机制

教学国家级中英双语示范课程《高级生理学》(2008年至2012)

指导研究生:已培养4名博士,36名硕士。在读博士生1名,硕士生10

近年主要论文著作:(标注*示通讯作者)

 

1. Dongmei Wang, Réjean Couture and Yanguo Hong*, 2014, Activated Microglia in the spinal cord underlies diabetic neuropathic pain. European Journal of Pharmacology, 728, 59-66.

 

2. Dongmei Wang, Yuanhui Huo, Rémi Quirion, Yanguo Hong*, 2014, Involvement of adrenomedullin in the attenuation of acute morphine-induced analgesia in rats. Peptides, 54:67-70.

 

3. Xueai Zeng, Mingyan Lin, Dongmei Wang, Yanding Zhang and Yanguo Hong*, 2014, Involvement of adrenomedullin in spinal glia activation following chronic administration of morphine in rats, European Journal of Pain, 18:867-876.

 

4. Dongmei Wang, Xiaolong Zhou and Yanguo Hong*, 2013, Effects of a combination of ketanserin and propranolol on inflammatory hyperalgesia in rats. European Journal of Pharmacology, 721, 126-132.

 

5. Dongmei Wang, Tingjun Chen, Xiaolong Zhou, Réjean Couture and Yanguo Hong*, 2013, Activation of Mas oncogene-related gene (Mrg) C receptors enhances morphine-induced analgesia through modulation of coupling of mu-opioid receptor to Gi-protein in rat spinal dorsal horn. Neuroscience, 253, 455-464.

 

6. Jianping Jiang, Dongmei Wang, Xiaolong Zhou, Yuping Huo, Tingjun Chen, Fenjuan Hu, Rémi Quirion and Yanguo Hong*, 2013, Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms. British Journal of Pharmacology, 170, 1027-1040.

 

7. Dongmei Wang, Liqin Ruan, Yanguo Hong*, Jean-Guy Chabot and Rémi Quirion, 2013, Involvement of PKA-dependent upregulation of nNOS-CGRP in adrenomedullin-initiated mechanistic pathway underlying CFA-induced response in rats, Experimental Neurology, 239:111-119.

 

8. Dongmei Wang, Tingjun Chen, Yun Gao, Rémi Quirion and Yanguo Hong*, 2012, Inhibition of SNL-induced upregulation of CGRP and NPY in the spinal cord and dorsal root ganglia by the 5-HT(2A) receptor antagonist ketanserin in rats, Pharmacology Biochemistry and Behavior, 101:379-386.

 

9. Yanguo Hong, Hay DL, Quirion R, Poyner DR, 2012, The pharmacology of Adrenomedullin 2/Intermedin, British Journal Pharmacology, 166:110-120.

 

10. Yanguo Hong, Dongmei Wang, Jean-Guy Chabot, Weiya Ma, Peiwen Chen and Rémi Quirion, 2010, A role for protein kinase C-dependent upregulation of adrenomedullin in the development of morphine tolerance in male rats, Journal of Neuroscience, 30:12508-12516.

 

11. Peiwen Chen, Dongmei Wang, Meili Li, Yanding Zhang, Rémi Quirion and Yanguo Hong*, 2010, Modulation of SNSR on the development of morphine tolerance and its neurochemical mechanisms, Journal of Neuroscience Research, 88:2952-2963.

 

12. Yanguo Hong, Yushan Liu, Jean-Guy Chabot, Alain Fournier and Rémi Quirion, 2009, Upregulation of adrenomedullin in the spinal cord and dorsal root ganglia in the early phase of CFA-induced inflammation in rats, Pain, 146:105-113.